hepatitis c virus is one of the main reasons for chronic liver disease and hepatocellular carcinoma. combination therapy with interferon (peg-ifn-α) and ribavirin (rbv) clear the virus more likely than the others. different factors like virus and host characteristics influence on response to treatment. the most important viral factors include virus genotype and viral load; host factors like gen...

The combined effects of tamoxifen, a competitive inhibitor of estrogen, and type I or II interferons on the proliferation of several human breast cancer cell lines in vitro were examined. Additive antiproliferative effects were observed with interferons and tamoxifen, in two estrogen receptor positive cell lines, MCF-7 and T-47D. In MCF-7 cells neither beta ser interferon, gamma interferon, nor...

IL-9 is a pleiotropic cytokine, for which an overarching role in humans remains elusive. Both interleukin 9 (IL-9) and its receptor, IL-9R, are specifically expressed by skin-tropic T helper 2 (TH2) cells. This suggests that signals play important cutaneous immunity allergy. Yet, the mechanism of action incompletely understood. In this study, we aimed at deciphering effect on TH cells allergic ...

Vitiligo is a relatively common, acquired depigmenting disease caused by the loss of epidermal melanocytes. Oxidative stress known to participate in initiation vitiligo triggering autoimmunity. In this study, we tried identify factors serving as bridge between oxidative and autoimmunity vitiligo. According RNA sequencing analysis on H2O2-treated melanocytes, interferon-stimulated gene 15 (ISG15...

As a DNA receptor in the cytoplasm, cyclic GMP-AMP synthase (cGAS) contributes to recognition of abnormal cytoplasm and stimulator interferon genes (STING) signaling pathway. cGAS could mediate expression interferon-related genes, inflammatory-related factors, downstream chemokines, thus initiating immune response. The STING protein is key effector It widely expressed across cell types such as ...

Background: Euphorbia plants are traditionally used in folk medicine for infections, inflammation, and cancer. Objectives: To investigate the effects of the butanolic extracts of Euphorbia micorociadia and Euphorbia osyridea on specific transcription factors and cytokines expression of T cell subsets. Methods: Activated mouse splenocytes were cultured in the presence of non-cytotoxic concentrat...

Background: Pegylated Interferon Alpha-2b is synthesized via the use of PEG (polyethylene glycol). It formulated attaching a 12kDa mono methoxy polyethylene glycol moiety to recombinant human protein. acts binding (JAK/STAT) Janus kinase signal transducer and activator transcription interferon receptor. The /Virafin binds (IFNAR1/2) alpha receptor 1 2. better known as Virafin has been approved ...

background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...

Interferon may be thought of as a key, with the interferon receptor as the signal lock: Crosstalk between them maintains their balance during viral infection. In this review, the protein structure of avian interferon and the interferon receptor are discussed, indicating remarkable similarity between different species. However, the structures of the interferon receptors are more sophisticated th...