نتایج جستجو برای: interferongamma
تعداد نتایج: 33 فیلتر نتایج به سال:
2. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emilie J-F, Levin M, et al. Interferonγ–receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N Engl J Med. 1996;26:1956–60. 3. Casanova JL, Blanche S, Emile JF, Jouanguy E, Lamhamedi S, Altare S, et al. Idiopathic disseminated bacillus CalmetteGuérin infection: a French national retrospective study. Pediatrics. 1996;98:774–...
The capacity of interferon-gamma to regulate the generation and release of leukotriene B4 (LTB4) from human alveolar macrophages ofnormal nonsmoking individuals was evaluated. When alveolar macrophages were incubated for 60 min with heat aggregated IgG (HAIgG), they generated and released 5.7±1.7 ng ofLT B4 per 106 cells compared to 1.9±0.4 ng from cells incubated with buffer alone, P = 0.02. W...
BACKGROUND We describe a case of a fever of unknown etiology that was caused by a caseating tubercle granuloma which produced erythropoietin. To our knowledge, this is the first report of an erythropoietin- producing granuloma. CASE PRESENTATION A 48-year-old Japanese man with a 5-year history of maintenance hemodialysis for diabetic nephropathy presented with an intermittent fever over a few...
OBJECTIVE To evaluate the accuracy of an interferongamma release assay (QuantiFERON-TB Gold in Tube) for diagnosing Mycobacterium tuberculosis infection in a young pediatric population. METHODS 195 children previously vaccinated with BCG were evaluated, being 184 healthy individuals with no clinical or epidemiological evidence of mycobacterial infection, and 11 with Mycobacterium tuberculosis...
Given their immune-modulating capacity, regulatory T cells (Treg) cells may be important players in the induction of the protective T-cell response (Th1) to genital chlamydial infection. Recent work has demonstrated that plasmacytoid dendritic cells (pDC) respond to genital chlamydial infection, and that pDC may be uniquely positioned for the induction of Treg cells during this infection. Here,...
Drugs used for remission induction therapy for childhood precursor-B acute lymphoblastic leukemia (ALL) are nonselective for malignant cells. Several garlic compounds have been shown to induce apoptosis of cancer cells and to alter lymphocyte function. To investigate the effect of garlic on the apoptosis of ALL cells and lymphocyte immune function, cells from newly diagnosed childhood ALL patie...
Large-scale cross-species DNA sequence comparison has become a powerful tool to identify conserved cisregulatory modules of genes. However, bioinformatic analysis alone cannot reveal how an evolutionarily conserved region regulates gene expression: whether it functions as an enhancer, silencer, or insulator; whether its function is cell-type restricted; and whether biologically relevant transcr...
1. Blake GJ, Ridker PM. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol 2003;41: S37–42. 2. Huber C, Batchelor JR, Fuchs D, et al. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferongamma. J Exp Med 1984;160:310–6. 3. Werner-Felmayer G, Werner ER, Fuchs D, et al. Pteridine biosyn...
Vogt-Koyanagi-Harada disease is an uncommon autoimmune disorder. Its pathophysiology is related to T-cell-mediated autoimmune processes directed against one or more antigenic components of melanocytes. The diagnosis of this condition is primarily based on clinical features including: ocular findings (granulomatous uveitis, choroiditis, exsudative retinal detachment, papillitis) neurological (me...
Nocturnal hormones and circadian rhythms in arthritis Circadian rhythms are driven by biological clocks and are endogenous in origin [1]. Therefore, circadian changes in the metabolism or secretion of endogenous glucocorticoids are responsible, in part, for the time-dependent changes observed in the immune/inflammatory response and related clinical symptoms (e.g., arthritis). Recently, another ...
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