Background: Sharing masked interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an important issue that can affect trial integrity. Our survey's objective is to collect evidence to understand how seemingly masked interim results or result extrapolations are interpreted and discuss whether these results should be shared at interim. Methods: Conducted a 6 scenario-q...

background: the interim restorative materials should have certain mechanical properties to withstand in oral cavity. the aim of this study was to evaluate the hardness and wear resistance ofinterim restorative materials. materials and methods: fifteen identical rectangular shape specimens with dimensions of 2 mm × 10 mm × 30 mm were made from 7 interim materials (tempspan, protemp 3 garant, rev...

Food and Drug Administration (FDA) clinical and statistical guidelines request that sponsors document considerations which will govern the conduct of interim analyses in clinical trials. These considerations include clearly stating the reasons for such interim analyses, the planned number of or the (information/calendar) times when the interim analyses will be carried out, adequate stopping rul...

Prosthodontic treatment sometimes requires a long-term interim fixed dental prosthesis (FDP) until the definitive restoration can be cemented. However, some interim materials are weak and do not have an adequate marginal seal. The CAD/CAM systems have developed considerably, offering accuracy and more options than previously. It can be envisioned that CAD/CAM technology developments will contin...

T lymphoblastic leukemia/lymphoma (T-ALL/LBL) is highly aggressive. Although intensive chemotherapies such as ALL-type regimens are commonly used, about half adult patients eventually relapse and die of T-ALL/LBL. Overwhelming evidences have confirmed that interim PET can predict survival outcomes and guide subsequent treatments in Hodgkin lymphoma. However, whether interim PET-CT can predict s...

signed digit (sd) number systems provide the possibility of constant-time addition, where inter-digit carry propagation is eliminated. such carry-free addition is primarily a three-step process; adding the equally weighted sds to form the primary sum digits, decomposing the latter to interim sum digits and transfer digits, which commonly belong to {–1, 0, 1}, and finally adding the transfers to...

Early response evaluation with [(18) F]fluordeoxyglucose (FDG) positron emission tomography after 2 cycles of chemotherapy (interim PET) has been indicated as the strongest predictor for outcome in classical Hodgkin lymphoma (HL). We studied the prognostic role of the number of tumor-infiltrating CD68+ cells and of the plasma levels of TARC (thymus and activation-regulated chemokine) in the con...

The information contained in an interim implant-supported fixed acrylic resin complete denture is a starting point for fabricating the definitive restoration. Duplicating this information in an expedient, precise, and sanitary fashion is desirable so that the interim restoration can be returned to the waiting patient. A technique is described to fabricate an accurate definitive polyvinyl siloxa...

Dr. Charles N. Bertolami, Herman Robert Fox Dean, New York University Dr. John D.B. Featherstone, Interim Dean, University of California, San Francisco Dr. André Fournier, Dean, Université Laval Dr. Jeffrey W. Hutter, Dean ad interim, Boston University Dr. Anthony M. Iacopino, Dean, University of Manitoba Dr. Nadine C. Milos, Acting Chair, University of Alberta Dr. Mark R. Patters, Interim Dean...