To observe the pro- and anti-inflammatory cytokine (TNF-α, IL-4, IL-6, IL-10) secretion from cultivated peripheral blood mononuclear cells (PBMCs) for 48h. Blood samples were obtained 42 women patients of Nadezhda Women’s Health Hospital after signing written informed consent. For PBMC isolation, 9 ml heparinised whole each patient processed by density gradient centrifugation using Pancoll (P04...

Abstract The aim of this study is to identify the active compounds essential oil extracted from Pinus densiflora (Sieb. et Zucc.) wood using hydrodistillation method and evaluate their anti-inflammatory activity. chemical composition was identified by GC–MS analysis, its activity assessed investigating effect on expression interleukin-4 (IL-4), interleukin-13 (IL-13), ? -hexosaminidase in lipop...

The aim of the present study is to investigate the preventive effect of pioglitazone on colitis induced with dextran sulfate sodium (DSS) in rats. Twenty-four male Sprague-Dawley rats weighing 180-200 g were randomized into four groups. Rats of the 1st group received only saline and served as normal group. Colitis was induced in the remaining 3 groups by 1.5% DSS administered in drinking water ...

allergic asthma is a multifactorial disease, influenced by genetic and environmental factors. recent family-based studies have revealed evidence for linkage of human chromosomes 5q31-33, 12q15-24, 11q13 and 15q23.6 as regions likely to contain genes related to asthma. among the candidate genes in these regions are the genes encoding for human interleukin-4, interleukin-13 and interleukin-16. to...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...

This study investigated the effect of ethanol stem bark extract Irvingia gabonensis (ESEIG) on sodium arsenite (SA)-induced pro-inflammatory cytokines and hematological perturbations in Wistar rats. Fifty-five rats weighing 100 g - 179 were distributed into eleven groups (n=5). Group 1 had feed water only. 2 received 4.1 mg/kg body weight (kgbw) SA. Groups 3-11 SA and/or ESEIG. Treatment was do...

The 4-ACGC isolated from BP was prepared to investigate the cardioprotective effects on attenuating chronic heart failure in vivo and in vitro. A chronic heart failure (CHF) rat model was established to investigate the cardioprotective effects of 4-ACGC. From this, several cardiac function indexes were recorded. The inflammatory markers including tumor necrosis factor-α (TNF-α), Interleukin-6 (...

Background: Obesity is associated with chronic inflammation in obese subjects, which leads to an increase of inflammatory cytokines. This study aimed to evaluate the effect of different intensity circuit resistance training on levels of interleukin 1 beta and interleukin-10 in obese men. Methods: In a semi-experimental trial during May to August 2020, 44 obese men from Tehran city were selecte...