Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Various conventional dosage forms have been employed for this purpose but they lack to provide the desired bioavailability of the drug due to poor residence time and faster clearance in the nasal cavity. Formulating multiparticulate system with mucoadhesive polymers may provide a significant in...

Key Points  Stereotactic radiosurgery is the delivery of a highly-focused beam of radiation to a target  It uses very high doses, but is highly conformal, so surrounding tissue toxicity is low  Tumours treated successfully include brain, intra-nasal, osteosarcoma, bladder, prostate, urethra, heart-base, liver  Treatments are typically delivered in 1-3 fractions with obvious benefits to the ...

Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. Here, we describe methodology that evaluates the suitability of candidate siRNA for respiratory administration. Chemically-modified siRNA exhibited ...

Abstract AIMS Several techniques, such as intra-cerebrospinal fluid chemotherapy, ultrasound-mediated blood-brain barrier disruption, convection enhanced delivery, polymer delivery systems, electric field therapy, and intra-arterial intra-nasal have the potential to transform treatment of brain tumours in children. However, there been very few clinical trials evaluate these. We aim address chal...

Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades. Intra-nasal administration of drugs offers an interesting alternative for achieving systemic therapeutic effects of drugs that are comparable to ...

BACKGROUND: Influenza outbreak has become a great lifethreateningdisease in the world. Nasal vaccines can inducesystemic IgG and mucosal IgA antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. Mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. Therefore, nas...

Introduction: Nasal bone fractures are one of the most common problems in patients who are referred to otolaryngology centers. We aimed to evaluate physical examination, sonography and conventional lateral nasal bone radiography in patients with nasal bone trauma and its relation to intra-operative findings. Methods: This prospective study was performed on 200...

Introduction: Lobular capillary hemangioma (LCH) is a benign lesion of vascular origin. It rarely involves nasal cavity which most commonly manifests as progressive nasal obstruction and epistaxis. Case Report: In this report we present a case of LCH of the nasal cavity which occurred approximately one month after delivery. There was no recurrence after complete endoscopic resection during ...