Intracellular recording is a powerful electrophysiology technique that has revealed much of what is known about the biophysical properties of neurons. However, neuronal properties are strongly affected by activity dependent and modulatory influences, making it essential, ultimately, to study these properties in behaving animals. Unfortunately, intracellular recording has only been widely applie...

Primer on physiological techniques Different recording techniques:-Intracellular recording-Extracellular recording-Imaging Intracellular recording Record inside the cell using glass (why not metal?) electrodes. $$ This technique allows the experimenter to record subthreshold responses, and to understand mechanisms behind a cell's response properties. Whole-cell recording is a modern form of int...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...