AIMS To investigate the prevalence of lymphocytic gastritis in patients with coeliac disease. METHODS Gastric biopsies from 70 patients with coeliac disease were examined by light microscopy for the presence of lymphocytic gastritis, defined as 25 or more intraepithelial lymphocytes/100 gastric columnar epithelial cells. RESULTS Lymphocytic gastritis was found in seven cases. Positive cases...

The simple quantitation of intraepithelial lymphocytes per 100 epithelial cells in small bowel has been a valuable addition to the study of the histopathology of celiac disease. However new technology is necessary to increase the accuracy and significance of the subtypes of intraepithelial lymphocytes in the differential diagnosis and the evaluation of gluten related disorders.

IL-2/IL-15R -deficient mice display impaired development of NK cells, NKT cells, and intraepithelial lymphocytes of the intestine and skin. To determine the role of survival signals mediated by IL-2/IL-15R in the development of these innate lymphocytes, we introduced a bcl-2 transgene into IL-2/IL-15R -deficient mice. Enforced expression of Bcl-2 restored the number of NK cells in IL-2/IL-15R -...

Abstract Elucidating the relationship between cellular metabolism and T cell function has substantially advanced our understanding of how cells are regulated in response to activation. The metabolic profiles circulating or peripheral have been well-described, yet less is known regarding complex local microenvironments shape modulate bioenergetic profile tissue-resident lymphocytes. Intraepithel...

The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells guarantee a first line of defense against pathogens and toxic molecules. Enterocytes maintain a physical barrier against microbes and directly contribute to the gut homeostasis by sampling th...

An estimate of the number of intraepithelial lymphocytes in jejunal villous epithelium can be obtained by differential counting of nuclei in the epithelium. From counts carried out in 160 jejunal biopsies from patients who did not have coeliac disease the normal range has been established as 6-40 intraepithelial lymphocytes per 100 villous epithelial cells. In some biopsies there was a moderate...