BACKGROUND Locoregional advanced melanoma poses a complex clinical challenge that requires a multidisciplinary, patient-centered approach. Numerous agents have been studied for their suitability as intralesional therapy in the past decades, but few have successfully completed phase 3 clinical trial testing. METHODS The relevant medical literature was searched for articles regarding use of int...

background cutaneous leishmaniasis (cl) is an endemic disease in iran. pentavalent antimonials including meglumine antimoniate (ma) are still the gold standard treatment. trichloroacetic acid (tca) is used in treatment of acne scar, photodamaged skin, and some other dermatologic diseases. considering the tca potential to induce collagen synthesis and its efficacy in the treatment of papular cl ...

BACKGROUND Dorsal wrist ganglia (DWG) are a common, benign soft-tissue mass of the wrist. Excision of DWG is a common procedure performed by hand surgeons and may be performed using either open or arthroscopic techniques. This study aims to evaluate the frequency of stalk visualization with intralesional injection of inert dye in the course of arthroscopic excision along with incidence of recur...

BACKGROUND Although intralesional methotrexate (MTX) is an effective, nonsurgical treatment of keratoacanthoma (KA), there have not been many reports of on the MTX treatment for KA in Korea. OBJECTIVE The purpose of this study was to evaluate the clinical efficacy of the intralesional MTX for the treatment of KA in Korean patients. METHODS We retrospectively studied seven patients with KA w...

The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL). We demonstrated that Treg cells preferentially accumulate in lesions from ACL patients during the early phase of infection (lesion duration of less than 1 month). In addition, levels of Foxp...

Although intralesional meglumine antimoniate (MA) infiltration is considered an option for cutaneous leishmaniasis (CL) therapy and is widely used in the Old World, there have been few studies supporting this therapeutic approach in the Americas. This study aims to describe outcomes and adverse events associated with intralesional therapy for CL. This retrospective study reviewed the experience...

AIM This review aimed to summarize the clinical outcomes in relation to tumor resection margins of cervical chordomas. METHODS Studies that described any surgical intervention for cervical chordoma were identified. Cervical chordomas with cranial or spinal extension, purely retropharyngeal chordomas or where resection type was not reported, were excluded from the study. RESULTS Seventy-six ...

Results: Response of skin warty lesions to treatment with intralesional 5-FU was as following: complete response was seen in 200 (80.0 %), partial response was seen in 37 (14.8 %) of cases and no response was recorded in 13 (5.2 %) of cases. There was no significant association between size of warty lesion and response to intralesional 5-FU (p = 0.154), but there was significant association bet...

PURPOSE To review the functional outcome and local recurrence rate of 29 patients who underwent segmental excision or intralesional curettage with adjuvant therapy for giant cell tumour (GCT) of bone. METHODS Records of 17 men and 12 women (mean age, 30.17 years) who underwent segmental excision (n=18) or intralesional curettage followed by adjuvant therapy (n=11) for GCT of the femur (n=13),...