نتایج جستجو برای: irf

تعداد نتایج: 1944  

Journal: :The Journal of Experimental Medicine 1997
Yoshifumi Tada Alexandra Ho Toshifumi Matsuyama Tak W. Mak

Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates interferon-induced genes and type I interferons. Recently, studies of IRF-l-deficient mice have revealed that IRF-I regulates the induction of molecules that play important roles in inflammation, such as inducible nitric oxide synthase (iNOS) and interleukin-l beta-converting enzyme (ICE). To study the role of IRF-1...

Journal: :Journal of immunology 2005
Tomohiko Tamura Prafullakumar Tailor Kunihiro Yamaoka Hee Jeong Kong Hideki Tsujimura John J O'Shea Harinder Singh Keiko Ozato

Dendritic cells (DCs) are bone marrow (BM)-derived APCs central to both innate and adaptive immunity. DCs are a heterogeneous cell population composed of multiple subsets with diverse functions. The mechanism governing the generation of multiple DC subsets is, however, poorly understood. In this study we investigated the roles of closely related transcription factors, IFN regulatory factor (IRF...

Journal: :Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005
Judith M Connett Linda Badri Thomas J Giordano William C Connett Gerard M Doherty

Interferon-gamma (IFN-gamma) is a pleiotropic cytokine with potent antitumor effects, both in vitro and in vivo. The antitumor activity of IFN-gamma is mediated in part through IFN regulatory factor-1 (IRF-1) and may be blocked by IRF-2. To test our hypothesis that some tumors escape the antitumor effects of IFN-gamma by cellular changes reflected in IRF-1 and IRF-2 expression, we examined IRF-...

2016
Yihe Yan Zhihai Liang Qiang Du Muqing Yang David A. Geller

Interferon regulatory factor-1 (IRF-1) is a tumor-suppressor gene induced by interferon-γ (IFNγ) and plays an important role in the cell death of hepatocellular carcinoma (HCC). HCC tumors evade death in part by downregulating IRF-1 expression, yet the molecular mechanisms accounting for IRF-1 suppression in HCC have not yet been characterized. Previous studies have shown that microRNA-23a (miR...

2008
Soo-In Yeon Ju Ho Youn Mi Hwa Lim Hye Ja Lee Young Mok Kim Ji Eun Choi Jae Myun Lee Jeon-So Shin

PURPOSE IRF-5 is a direct transducer of virus-mediated and TLR-mediated signaling pathways for the expression of cytokines and chemokines which form homodimers or heterodimers with IRF-7. However, direct IRF-5-specific monoclonal antibodies (mAbs) are not available at present. These could be used to further evaluate the functions of IRF-5. In this study, we produced and characterized three mous...

Journal: :Viruses 2021

Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression neighboring suppress replication. III IFNs have similar properties, however their effects limited epithelial at mucosal surfaces due restricted the type IFN receptor. Rotavirus (RV) replicates intestinal that respond predominantly IFNs, it has been shown rath...

2010
Seung-Hee Jo Jonathan H. Schatz Jaime Acquaviva Harinder Singh Ruibao Ren

Interferon regulatory factor 4 (IRF-4) plays important functions in Band T-cell development and immune response regulation and was originally identified as the product of a proto-oncogene involved in chromosomal translocations in multiple myeloma. Although IRF-4 is expressed in myeloid cells, its function in that lineage is not known. The closely related family member IRF-8 is a critical regula...

Journal: :International immunology 2005
Kayo Yoshida Kazuo Yamamoto Tomoko Kohno Noriko Hironaka Kiyoshi Yasui Chojiro Kojima Hiroshi Mukae Jun-ichi Kadota Shoichi Suzuki Kiri Honma Shigeru Kohno Toshifumi Matsuyama

IFN regulatory factor-4 (IRF-4) is a transcription factor that is involved in the development and the functions of lymphocytes, macrophages and dendritic cells. Despite their critical roles in immune system regulation, the target genes controlled by IRF-4 are poorly understood. In this study, we determined the consensus DNA-binding sequences preferred for IRF-4 by in vitro binding site selectio...

Journal: :Nucleic Acids Research 2005
Christina A. Ortmann Andreas Burchert Katharina Hölzle Andreas Nitsche Burghardt Wittig Andreas Neubauer Manuel Schmidt

Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis of CML. Promoter methylation of CpG target sites or direct deletions/insertions of genes are mec...

Journal: :PLoS ONE 2009
Long Yang Tiejun Zhao Xiaoliu Shi Peyman Nakhaei Yunling Wang Qiang Sun John Hiscott Rongtuan Lin

BACKGROUND Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation. Activation of IRF-5 results in the production of pro-inflammatory cytokines such as TNFalpha, IL6 and IL12p40, as well as type I interferons. METHODOLOGY/PRINCIPAL FINDINGS In this study,...

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