hepatitis is the infections of a common cause disease among poly transfused patients. hepatitis c is slowed progression and inducing hcc. this study assessed hcc incidences, the role of iron and possible antitumor activity of chelators in 170 thalassemia patients using deferoxamine (dfo) therapy. they are diagnosed with hepatitis c due to positive pcr-rna. they are treated with ifn. the follow ...

The industry standard iron source for algae culture is in most cases Ethylenediaminetetraacetic acid ferric sodium salt (Fe-EDTA). During algae production pH and light intensity are not favorable for maintaining the integrity of the Fe-EDTA complex. As a consequence, iron availability becomes the limiting factor for growth. A series of growth studies and biomass determinations with a selection ...

The cornerstone of the treatment of Wilson’s disease is a reduction of copper levels in vivo using the orallyadministered chelating agents D-penicillamine and trientine dihydrochloride. Patients with side-effects from receiving multiple blood transfusions for the amelioration of inherited anaemias are also successfully treated with chelating agents. Blood transfusion elevates these patients’ ir...

Aspects of the kinetics and thermodynamics of the iron-catalysed Haber-Weiss reaction are discussed with special emphasis on the potential in vivo sources of iron. In addition, the properties of the iron chelates that inhibit the Haber-Weiss reaction are considered.

today, the bidentate ligands 3-hydroxypyridin-4-ones (hpos) as orally active iron chelating agents have been demonstrated to possess potential for treatment of some human diseases such as iron-overload in thalassaemic patients and malaria. in this research, a series of hpos with different substitutes and position were theoretically invest

iron overload is a clinical problem which can be prevented by using iron chelating agents. an alternative method of relieving iron overload is to reduce iron absorption from the intestine by administering specific iron chelating agents, which can bind iron to form nonabsorbable complexes. based on this strategy, a series of polymeric ligands containing the chelating moiety 3-hydroxypyridin-4-on...

a series of ortho -hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. n 1 -h hydroxypyridinones va , vb , and ve were the best radical scavengers in dpph free radical scavenging assay. compound vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. all of the synthesized compounds had very close chelating...

Today, the bidentate ligands 3-hydroxypyridin-4-ones (HPOs) as orally active iron chelating agents have been demonstrated to possess potential for treatment of some human diseases such as iron-overload in thalassaemic patients and malaria. In this research, a series of HPOs with different substitutes and position were theoretically invest

The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. Having up to five metal-carbon bonds in the equatorial plane has not been previously observed in transition metal chemistry. Density functional theory calculations showed that...