BACKGROUND Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage. This study presents data related to Hp phenotypes and ceruloplasmin ferroxidase activity in relation to iron store markers in patients with β-thalassemia major. METHODS Blood specimens were collected from 196 subjects (124 β-thalassemia major patients and 72...

Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Patients with HH and Hfe-deficient (Hfe / ) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in resp...

Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in resp...

Background: Iron deficiency anemia is one of the important problems during pregnancy.  Iron deficiency has several adverse effects on pregnant women and their newborns. Objective: To determine the status of iron store in newborns born to mothers with iron deficiency anemia. Methods: In a cross-sectional study, 90 mothers were categorized into three groups according to their pre-delivery hemoglo...

Ferritins are the main iron storage proteins found in animals, plants, and bacteria. The capacity to store iron in ferritin is essential for life in mammals, but the mechanism by which cytosolic iron is delivered to ferritin is unknown. Human ferritins expressed in yeast contain little iron. Human poly (rC)-binding protein 1 (PCBP1) increased the amount of iron loaded into ferritin when express...

The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution. Hepcidin acts by causing the degradation of its receptor, the cellular iron exporter ferroportin. The loss of ferroportin decreases iron flow into plasma from absorptive enterocytes, from macrophages that recycle the iron of senescent erythrocytes, and from hepatocyt...

What is Hemochromatosis? Iron storage disease, technically known as hemochromatosis, occurs when too much iron accumulates in the liver and other major organs of the body. The body needs a certain ,amount of iron to produce hemoglobin, which is the means of transporting oxygen molecules from the lungs to all the other cells in the body. However, when too much iron builds up, the body begins to ...

introduction: iron deficiency anemia is an important limiting factor for the number of donations in regular donors. limited data is available on the iron status in iranian donors. this study was conduced to evaluate the prevalence of iron deficiency and its related factors in blood donors at shiraz blood transfusion centre in 2005. methods: this descriptive study was done on all blood donors wh...