OBJECTIVE For middle aged and elderly subjects there is a concern that increased iron intake, especially heme iron associated with consumption of red meat, leads to increased iron stores resulting in disturbed glucose homeostasis and risk for cardiovascular disease and certain types of cancer. The aim of this study was to investigate the influence of heme, non-heme and iron supplementation on i...

The iron balance of 25 adolescent dancers and 23 control females of the same age were studied. The concentrations of fasting blood haemoglobin, serum iron, serum transferrin and serum ferritin were determined. Iron supplementation (ferrous sulphate corresponding to 100 mg of elemental iron per day) was instigated if body iron stores were low (serum ferritin < 30 gg.l-1). Blood samples were draw...

In individuals with similar body stores of iron, the amount of iron absorbed from a single oral dose is not proportional to the amount of iron administered. Although a greater amount of iron is absorbed as the size of the oral dose increases, the percentage or fraction of the dose that is absorbed actually decreases (1-3). In addition, the amount of iron absorbed from a given dose is dependent ...

BACKGROUND Results of cross-sectional studies suggest that in healthy people, iron absorption adapts to meet physiologic needs and stabilize iron stores, but this has not been adequately tested in longitudinal studies. OBJECTIVE We tested whether heme- and nonheme-iron absorption decrease in response to increased iron intake and whether iron stores reach a steady state. DESIGN In a randomiz...

Remarkable progress was recently achieved in the studies on molecular regulators of iron metabolism. Among the main regulators, storage iron, iron absorption, erythropoiesis and hepcidin interact in keeping iron homeostasis. Diseases with gene-mutations resulting in iron overload, iron deficiency, and local iron deposition have been introduced in relation to the regulators of storage iron metab...

Background: High body iron stores may increase the risk of several chronic diseases. Whether dietary factors contribute to the risk of high iron stores is unknown. Objective: We assessed the relation between dietary factors and the risk of high iron stores in the elderly Framingham Heart Study cohort. Design: We examined the relation between the usual intake of dietary factors (food-frequency q...

The relationship between the serum ferritin concentration and total body iron stores was investigated in 41 patients with idiopathic haemochromatosis and 199 first or second degree relatives. Thirty-two relatives (16.1%) had increased iron stores and serum ferritin levels were increased in all but one of them. The false-positive rate in the relatives with normal iron stores was 1.8% compared wi...

As a quantitative test of iron storage the six-hour urinary excretion of iron was measured after the intravenous infusion of the iron-chelating agent diethylenetriamine penta-acetic acid (D.T.P.A.). The value of this test in determining the presence and magnitude of the total body iron stores was assessed in patients with diseases of iron storage. In patients with idiopathic haemochromatosis an...

AIMS [Formula: see text] multislice multiecho cardiac magnetic resonance (CMR) allows quantification of the segmental distribution of myocardial iron overload (MIO). We evaluated whether a preferential pattern MIO was preserved between two CMR scans in regularly chelated thalassaemia major (TM) patients. METHODS AND RESULTS We evaluated prospectively 259 TM patients enrolled in the MIO in Tha...

background: obesity is associated with increased lipid peroxidation. it has also been suggested that risk of lipid peroxida­tion increases with increasing body iron stores. the aim of this study was to examine the association of body iron status with the concentration of plasma malondialdehyde (p-mda) as a marker of lipid peroxidation in obese and non-obese women. methods: in a case control stu...