quinazolinone derivatives are essential units in a wide range of relevant pharmacophores with a broad spectrum of abilities. due to their wide range of pharmacological and therapeutic activities including anticonvulsant, anti-inflammatory, hypolipidemic, anticancer, and anti-ulcer, the synthesis of quinazolinone moieties as a privileged class of fused heterocyclic compounds, have received much ...

A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use Surfactant, water as reaction medium, room temperature, high yield ease purification made the process very effective ecofriendly in nature. To demonstrate wide scope Isatoic anhydride Isatin used rea...

A simple and efficient procedure has been developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives under solvent-free conditions. This method uses the condensation of isatoic anhydride, aldehydes, and amines in the presence of a catalytic amount Sulfonated Porous Carbon (SPC). One of the important advantages of the new method is that the SPC could be recycled and reused.

A simple and efficient procedure has been developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives under solvent-free conditions. This method uses the condensation of isatoic anhydride, aldehydes, and amines in the presence of a catalytic amount Sulfonated Porous Carbon (SPC). One of the important advantages of the new method is that the SPC could be recycled and reused.

In this paper, magnetic chitosan is used as a support for the immobilization of copper catalyst (Cu@MChit). The fabricated successfully synthesized and characterized by several techniques. activity Cu@MChit evaluated in synthesis novel derivatives 3-alkyl-2-arylthio-2,3-dihydroquinazolin-4(1H)-ones. products are three simple steps via Chan–Lam coupling reaction. synthetic route based on reactio...

A commercially available Argonaut VacMaster-96 plate-to-plate solid-phase extraction (SPE) station equipped with 24 FluoroFlash cartridges is employed for parallel purification of fluorous reaction mixtures. Each cartridge charged with 3 g of fluorous silica gel has the capability to produce up to 100 mg of purified small molecules. The 24-well receiving plate has a standard footprint that can ...

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, I.R. Iran. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, 1936773493, Tehran, Iran. [email protected]. Abstract: In this study we have developed a simple, cheap, and rapid method for purification of 6×histidine-tagged recombinant proteins with high yields. The new immobil...