In this paper we develop a Bayesian statistical inference approach to the unified analysis of isobaric labelled MS/MS proteomic data across multiple experiments. An explicit probabilistic model of the log-intensity of the isobaric labels' reporter ions across multiple pre-defined groups and experiments is developed. This is then used to develop a full Bayesian statistical methodology for the id...

We perform molecular dynamics simulations of the glass transition through isobaric and isochoric cooling of a model polymeric material. In general, excellent agreement between the simulation results and the existing experimental trends is observed. The glass transition temperature (Tg) is found to be a function of pressure under isobaric conditions and specific volume under isochoric conditions...

A dependence of the isobaric ratio Y(3H)/Y(3He) on the N/Z ratio of the reconstructed quasiprojectile for the reaction of 28Si beam with 112,124Sn targets at two different projectile energies of 30 and 50 MeV/nucleon is presented. We demonstrate a linear dependence of the observable ln(Y(3H)/Y(3He)) on the N/Z ratio of the quasiprojectile and show the dependence of the slope on the reconstructe...

Polygalacturonase (PG) was extracted from tomato fruit. The inactivation kinetics of the PG crude extract was investigated under isothermal and isobaric-isothermal conditions. Thermal inactivation of tomato PG in the temperature range 58 to 65 8C could be described by a fractional conversion model, and in the temperature range from 70 to 90 8C by a biphasic model. Pressure-temperature inactivat...

Chemical labeling of peptides prior to shotgun proteomics allows relative quantification of proteins in biological samples independent of sample origin. Current strategies utilize isobaric labels that fragment into reporter ions. However, quantification of reporter ions results in distorted ratio measurements due to contaminating peptides that are co-selected in the same precursor isolation win...

Shell-model calculations have been carried out for isospin-forbidden P-delayed proton emission for Is-Od-shell nuclei. The process in which a nucleus near the proton drip line P+ decays by a superallowed transition to the isobaric analog state in the daughter nucleus is considered. The first complete set of calculations for the subsequent isospin-forbidden particle decay of the isobaric analog ...

BACKGROUND/AIMS We used high-resolution impedance manometry (HRIM) to determine the length of breaks on the isobaric contour which would predict incomplete bolus clearance in patients in the sitting position. METHODS In total, 651 swallows in 71 patients with esophageal symptoms were studied using a solid-state HRIM system in the sitting position. Each swallow was classified as complete or in...

Brachial artery diameter and compliance were measured in 23 normotensive control subjects and 49 hypertensive patients. The results were compared in isobaric conditions by a modeling analysis extrapolating from the measured data a short segment of the pressure-diameter and pressure-compliance curves in the artery. A logarithmic diameter-pressure function was used as well as measurements of brac...