OBJECTIVE To establish the role of TRPV1 receptor in the antinociceptive effect of natural alkamides (i.e. affinin, longipinamide A, longipenamide A and longipenamide B) isolated from Heliopsis longipes (A. Gray) S.F. Blake and some related synthetic alkamides (i.e. N-isobutyl-feruloylamide and N-isobutyl-dihydroferuloylamide). METHODS The orofacial formalin test was used to assess the antino...

The electrochemical corrosion prevention of engines and mechanisms is a task great national, economic defense importance. Lubricating oils commonly used in engineering do not have sufficient protective properties are unable to effectively protect it from corrosion, both during operation short-term long-term inactivity. One the simplest most rational ways solve this problem use lubricants contai...

Well-established label in biomolecules analysis, fluorescein isothiocyanate is commercially available its two different isomers with equal fluorescence sensitivity, differing meta- vs. para-isothiocyanate position. It was found this study that the stability of depends on polarity solvents and pyridine (stabiliser) presence. The lowest has water solvent. In acidic solution, their quinoid (acid) ...

A structure-activity relationship study was carried out to identify structural features in arylalkyl and alkyl isothiocyanates that are associated with the inhibitory potency of these compounds against lung tumorigenesis induced in A/J mice by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). These features include the alkyl chain length, phenyl substitution...

A study was carried out in order to determine the effect of vitamins (biotin, thiamine, pantotheniic acid and pyridoxal) and micronutrient (zinc, boron, manganese and iron) deficiencies on higher alcohol production during alcoholic fermentation with the industrially used yeast Saccharomyces cerevisiae M-300-A. Zinc deficiency induced a reduction on the levels of isobutyl and isoamyl alcohols. A...

Processing of lignocellulosic biomass or organic wastes produces a plethora of chemicals such as short, linear carboxylic acids, known as carboxylates, derived from anaerobic digestion. While these carboxylates have low values and are inhibitory to microbes during fermentation, they can be biologically upgraded to high-value products. In this study, we expanded our general framework for biologi...