there exists an association between pi3k pathway licentious activity and the considerable feature of high metastatic potential of the genitourinary cancer cells. although du 145 and 5637 have functional phosphatase and tensin homolog (pten) tumor suppressor gene, which antagonizes pi3k function, pc-3 is null for pten gene. in pursuit to explain why pten bearing cell lines display high metastati...

Background Asthenozoospermia accounts for almost 50% of the cases of male infertility. Our study investigating phosphoproteins differentially expressed in asthenozoosperm has identified the phosphoproteins relevant to sperm motility and the signature molecules likely to be altered in asthenozoospermia. The 66 phosphoproteins differentially expressed included four alpha tubulin isoforms which we...

The response to glucocorticoids (GCs) therapy classifies severe refractory asthma (SRA) and mild asthma, so the glucocorticoid receptors (GCRs) gene expression may be involved in SRA pathogenesis. Thus, it is aimed to compare the expression levels of two GCR isoforms (GCRα and GCRβ) in SRA, mild asthmatics, and healthy controls. Total RNA was isolated from the peripheral blood mononuclear lymph...

Short crop height is the preferred breeding trait since there a positive correlation between lodging resistance and yield increase. Alternative splicing can alter transcriptome diversity contribute to plant adaptation environmental stress. We characterized transcriptomes obtained from dwarf normal soybean lines derived cross of Glycine max var. Peking (G. max) G. soja IT182936 in an F7 RIL popu...

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

in this study, we investigated the cardioprotective effects of resveratrol. rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

Transforming growth factor betas (TGF?s) are one of the most widespread and versatile cytokines. The three mammalian TGF? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. Functions of TGF?s has a wide spectrum ranging from regulating cell proliferation and differ...

Abstract Third-generation sequencing is able to read full-length transcripts and thus efficiently identify RNA molecules transcript isoforms, including length splice isoforms. In this study, we report the time-course profiling of effect bovine alphaherpesvirus type 1 on gene expression epithelial cells using direct cDNA carried out MinION device Oxford Nanopore Technologies. These investigation...

Human d-aspartate oxidase (hDASPO) is a FAD-dependent enzyme responsible for the degradation of (d-Asp). In mammalian central nervous system, d-Asp behaves as classical neurotransmitter, it thought to be involved in neural development, brain morphology and behavior, appears several pathological states, such schizophrenia Alzheimer's disease. Apparently, human DDO gene produces alternative trans...