OBJECTIVE To assess the efficacy of managing pregnancies complicated by anti-Kell isoimmunization using the methods developed for evaluating anti-Rh-D isoimmunization. METHODS We reviewed 156 anti-Kell-positive pregnancies seen from 1959 to 1995, which were managed with serial maternal titers, amniotic fluid deltaOD450 determination, and funipuncture. Data on maternal titers, paternal phenoty...

Active immune mechanism in the female reproductive tract may produce high levels of anti-seminal/sperm antibodies. Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility. The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women. We focus on the distribution of serum seminal/sper...

LLOWING Landsteiner’s brilliant description in I9oo-19o1” 2 of the four blood groups, transfusions gradually became on the whole a safe and routine procedure. However, intragroup transfusion reactions were still observed in two groups of cases: (0 patients who had previously received a series of uneventful transfusions, and (2.) women at the very first transfusion associated with pregnancy. It ...

Fifteen per cent. of all cases of Rh-isoimmunization end in stillbirth. Until 1963 the only available means of preventing this outcome in cases with a high risk of stillbirth was to deliver the foetus prematurely before intrauterine death had occurred. The value of this was limited, because many intrauterine deaths due to haemolytic disease of the newborn occur early in pregnancy, and because i...