Context. Maximal voluntary isometric contraction, a method quantitatively assessing muscle strength, has proven to be reliable, accurate and sensitive in amyotrophic lateral sclerosis. Hand-held dynamometry is less expensive and more quickly applicable than maximal voluntary isometric contraction. Objective. To investigate if hand-held dynamometry is as reliable and valid as maximal voluntary i...

High-load isometric exercise is considered an effective countermeasure against muscle atrophy, but therapeutic electrical stimulation for muscle atrophy is often performed without loading. In the present study, we investigated the combined effectiveness of electrical stimulation and high-load isometric contraction in preventing muscle atrophy induced by hindlimb unloading. Electrical stimulatio...

When the mode of contraction of the cat papillary muscle is changed abruptly from isotonic to isometric, the tension of the first isometric contraction is as much as 22% greater and lasts substantially longer than the subsequent stable isometric contractions attained after a few beats. This previously undescribed phenomenon is largely independent of preload or inotropic influences, but is great...

Cyclic contraction and relaxation of plasmodial strands of Physarum polycephalum were measured under both isotonic and isometric conditions, and their relation to changes in microfilament (MF) morphology was investigated. The contraction-relaxation rhythm of a strand segment was insignificant and irregular immediately after isolation from the mother plasmodium. It became regular half an hour la...

BACKGROUND While the application of compressive joint loads and thigh muscle activity are associated with anterior tibial translation in vitro, less is known during early load acceptance in vivo. We investigated the effects of increasing axial loads on anterior tibial translation and thigh muscle activity in healthy knees during transition from non-weight bearing to early weight bearing. METH...

Resistance training with eccentric contraction has been shown to augment muscle hypertrophy more than other contraction modes do (i.e., concentric and isometric contraction). However, the molecular mechanisms involved remain unclear. The purpose of this study was to investigate the effect of muscle contraction mode on mammalian target of rapamycin complex 1 (mTORC1) signaling using a standardiz...