background: recently, stem cells have been considered for the treatment of heart diseases, but no marked improvement has been recorded. this is the first study to examine the functional and histological effects of the transplantation of human amniotic mesenchymal stromal cells (hamscs) in rats with heart failure (hf). methods: this study was conducted in the years 2014 and 2015. 35 male wistar ...

Myocardial infarction (MI) is a common presentation of the ischemic heart disease. Lavandula angustifolia is a herbaceous plant with antioxidative effects.This study was designed to investigate the cardioprotective effects of lavandula angustifolia essential oil against isoproterenol-induced MI in rats.The dried sample was subjected to hydrodistillation by using a Clevenger and the oils were dr...

Background and Aims : Hyperactive poly(ADP-ribose) polymerases (PARP) promote ischemic heart failure (IHF) after myocardial infarction (MI). However, the role of Tankyrases (TNKSs), members PARP family, in progression IHF remains unknown. We aimed to explore TNKSs pathophysiological process therapeutic potential TNKS inhibition for IHF.Methods: Cardiac samples from patients MI rats were employe...

RATIONALE Only a small portion of the known heritability of cardiovascular diseases, such as heart failure, can be explained based on single-gene mutations. Chromatin structure and regulation provide a substrate through which genetic differences in noncoding regions may affect cellular function and response to disease, but the mechanisms are unknown. OBJECTIVE We conducted genome-wide measure...

Jin YT, Hasebe N, Matsusaka T, Natori S, Ohta T, Tsuji S, Kikuchi K. Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and -adrenergic desensitization. Am J Physiol Heart Circ Physiol 292: H1593–H1599, 2007. First published November 17, 2006; doi:10.1152/ajpheart.00985.2006.—Sympathetic nervous activation is a crucial compensatory mechanism in heart failure. However, excess c...

OBJECTIVE Viscum album L. has favorable cardiovascular effects including antihypertensive and vasorelaxant activity, and the nitric oxide (NO) pathway upregulation has been proposed to be the underlying mechanism. NO also plays an important role in the pathophysiology of heart failure. However, its effects on cardiac systolic function are unclear. METHODS A total of 30 male Wistar albino rats...

Myocardial infarction (MI) is a common presentation of the ischemic heart disease. Lavandula angustifolia is a herbaceous plant with antioxidative effects.This study was designed to investigate the cardioprotective effects of lavandula angustifolia essential oil against isoproterenol-induced MI in rats.The dried sample was subjected to hydrodistillation by using a Clevenger and the oils were dr...

BACKGROUND Myocyte apoptosis plays an important role in pathological cardiac remodeling and the progression of heart failure. cAMP signaling is crucial in the regulation of myocyte apoptosis and cardiac remodeling. Multiple cAMP-hydrolyzing phosphodiesterases (PDEs), such as PDE3 and PDE4, coexist in cardiomyocytes and elicit differential temporal/spatial regulation of cAMP signaling. However, ...