Background: As a T helper type 1 (Th1) derived cytokine, Interferon gamma (IFN-γ) is an important regulator of inflammatory immune responses. Furthermore, IFN-γ plays an essential role in defense against tumors and intracellular pathogens. This study was designed to assess the pattern of IFN-γ production in human leukemic (Jurkat and Molt-4) T cell lines in vitro. Methods: Ju...

Background: Recently, modification of T cells with chimeric antigen receptor (CAR) has been an attractive approach for adoptive immunotherapy of cancers. Typically, CARs contain a single-chain variable domain fragment (scFv). Most often, scfvs are derived from a monoclonal antibody of murine origin and may be a trigger for host immune system that leads to the T-cell clearance. Nanobody is a spe...

background: radiation-induced bystander effect is a response which results in damage in non-irradiated cells in response to signals from the irradiated cells. the aim of the present study was to investigate microwave-induced bystander effect from a gsm mobile phone simulator on induction of apoptosis in jurkat cell line. materials and methods: jurkat cells were divided into three groups of non-...

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

abstract the antineoplastic activities of alcoholic and aqueous extracts of the roots, stems and leaves of isatis campylocarpa an endemic species of the brassicaceae family from iran, investigated on the growth of jurkat as an acute lymphocytic leukemia cell line, k562 as a chronic myelogenous leukemia cell line and fen as a bladder cancer cell line using colorimetric assay. results showed that...

background: leukemia is a malignant proliferative disorder of the hematopoietic cells. the important role of angiogenesis in leukemia has been reported by several studies. matrix metalloproteinases (mmps) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. objective: the present study was conducted to evaluate the patterns of ...

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

background: sodium arsenite (naaso2) has potent cytotoxic activity in human cancer cells. oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. the purpose of the present study was to evaluate the alteration of mrna levels of catalase ( cat ) and superoxide dismutase 2 ( sod2 ) in mcf-7 and jurkat cells after exposure to naaso 2 . methods: methylthiazol tetrazol...

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

Lectins (carbohydrate-binding proteins) are able to distinguish different patterns of glycosylation on cell surfaces. This study investigated the effects lectins from Alpinia purpurata inflorescence (ApuL) and Schinus terebinthifolia leaf (SteLL) viability human leukemia cells (K562, chronic myeloid leukemia; JURKAT, acute lymphoblastic leukemia) mesenchymal stem (MSCs) umbilical cords. In addi...