The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 3(2) factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concent...

Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast d...

Many studies have tried to look for the application of chitosan in tissue engineering since its structure is similar to glycoaminoglycans, the main components of the extracellular matrix. Previous studies had indicated that the incorporation of sulfonic or phosphonic functionalities would be beneficial to the growth of certain cells. However, no study has explored the effect of incorporation o...

The objective of this study was the preparation ionically crosslinked 6-mercaptopurine (6-MP) monohydrate microparticles through preparing polyelectrolyte complexes drug and polymers. Polymers such as chitosan, casein, carrageenan were used to prepare microparticles, sodium tripolyphosphate crosslinker. Microparticles characterized for their flow behavior, compressibility, percentage yield, mic...

A polymer-based gene delivery system, denoted as “DNA/polycation/polyanion”, is designed based on the concept of polyelectrolyte multilayer fabrication by the layer-by-layer polyelectrolyte self-assembly technology. The comparisons of the physicochemical properties between ‘core’ DNA/branched polyethylenimine (PEI) and DNA/chitosan complexes suggest that DNA/PEI complexes form as colloidally st...

Cancer is the most fatal disease of last century after cardiovascular disease. Gemcitabine a nucleosideanalogue used in treatment cancer. However, like many anticancer drugs, it has side effects thatlimit treatment. A nano drug delivery system been developed to provide effective by reducingside effects. Chitosan and κ-carrageenan, which are regarded as safe FDA, were preparationof system. In sy...

Here we present a novel matrix-mimetic nanoassembly based on polysaccharides. Chitosan electrospun fiber networks are decorated with heparin-containing polyelectrolyte complex nanoparticles (PCNs) that present basic fibroblast growth factor (FGF-2), both stably adsorbed to the surfaces and released into solution. These FGF-2/PCN complexes can be released from the fibers with zero-order kinetics...

AIM This paper is a short review on the state-of-the-art of the use of polyelectrolyte complexes containing polysaccharides for wound and burn healing and treatment using the chitosan/hyaluronic acid polyelectrolyte complex (PEC) hydrogel. RESULTS AND CONCLUSIONS PEC is suitable for wound healing because a wet treatment can be realized and both components of PEC contribute by their properties...

Biomaterials based on polyelectrolyte complexation are an innovative concept of coatings and packaging production to be applied in a wide range of food products. The aim of this study was to obtain and characterize a sodium alginate–chitosan complex material with variable degree of polyion interactions by complexation of oppositely charged polysaccharides. In order to characterize polyelectroly...