AIMS We sought to define the underlying mechanisms for atrial fibrillation (AF) during chronic heart failure (HF). METHODS AND RESULTS Preliminary studies showed that 4 months of HF resulted in irreversible systolic dysfunction (n = 9) and a substrate for sustained inducible AF (>3 months, n = 3). We used a chronic (4-month) canine model of tachypacing-induced HF (n = 10) to assess atrial ele...

Reaction F + CH4 → HF CH3 (1) has been studied using a discharge flow reactor combined with mass spectrometry in the temperature range 220–960 K. The rate constant of reaction was determined both absolute and relative measurements: k1 = (1.28 ± 0.04) × 10−10 exp(−(219 9)/T) cm3molecule−1s−1 (the uncertainties represent precision at 2σ level, estimated total uncertainty on being 15% all temperat...

Alternative permanent-magnet materials with intermediate performance, such as K1 , are investigated experimentally. Our focus is on the structural and magnetic properties of bulk YCo5-xFex and on rare-earth-free transition-metal alloys such as TMxCo100-x (TM = Zr, Hf). YCo5-xFex alloys (x = 0 to 0.75), which crystallize in the hexagonal CaCu5-type structure, exhibit an improved of anisotropy an...

This paper presents a new adaptive terminal sliding mode tracking control design for a class of nonlinear systems using fuzzy logic system. The terminal sliding mode control (TSM) was developed to provide faster convergence and higher-precision control than the linear hyperplane-based sliding control. However, the original TSM encountered singularity problem with discontinuous control action. M...

beta-catenin signaling is one of the key factors regulating the fate of hair follicles (HFs). To elucidate the regulatory mechanism of embryonic HF fate determination during epidermal development/differentiation, we analyzed conditional mutant mice with keratinocytes expressing constitutively active beta-catenin (K5-Cre Catnb(ex3)fl/+). The mutant mice developed scaly skin with a thickened epid...

The monitoring and regulation of one's own physiological reactions and cardioregulatory abnormalities are central to the aetiology and maintenance of social anxiety disorder (SAD). We therefore explored the neural correspondences of these heart rate alterations. 21 patients with SAD and 21 matched healthy controls (HCs) underwent 3T-fMRI scanning. Simultaneously, high-frequency heart rate varia...

background: radio-adaptive response and bystander effects are known phenomena occurring in cells following exposure to ionizing radiation (ir). in this study we examined possible radio-adaptation of lymphocytes following bystander effects induced by cho-k1 cells. materials and methods: whole blood and cho-k1 cells were cultured in rpmi-1640 complete medium. cells were separately irradiated with...

Vitamin K is required for the hepatic production of blood coagulation factors II, VII, IX and X. The term vitamin K refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. Vitamin K1 (phylloquinone) occurs in green plants, while vitamin K2 (menaquinone) is synthesized by microbial in the gut. The recommended dose of vitamin K in neonates is 1 mg intramuscularly. For infants...

background: klebseilla pneumoniae causes urinary tract infections, nosocomial pneumonia and intra-abdominal infections. capsular antigens are considered to be the ultimate virulence determinants. among 77 capsular serotypes of k. pneumoniae, serotypes k1 and k2 are the most virulent ones in humans. objectives: we designed a pcr method for detection of capsular serotypes k1 and k2 of k. pneumoni...

The paper aims at developing the most simplified axiom for a pseudo (k0, k1)-covering space. To make this success, we need to strongly investigate some properties of weakly local (WL-, short) k1)-isomorphism. More precisely, initially prove that digital-topological imbedding w.r.t. k1)- isomorphism implies WL-(k0, Besides, while k1)-isomorphism is proved be k1)-continuous map, it not surjection...