PURPOSE Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor. The purpose of the present study was to evaluate the therapeutic effect of K5 on alkali-burn-induced corneal neovascularization (NV) and to investigate its mechanism of action. METHODS Corneal NV was induced in rabbits by NaOH. The rabbits received eye drops containing K5 or vehicle alone, four times per day. Corneal NV and ...

Let Km −H be the graph obtained from Km by removing the edges set E(H) of H where H is a subgraph of Km. We use the symbol A3 to denote P2 ∪K2. In this paper, we characterize the potentially K5 − P3, K5 −A3, K5 −K3 and K5 −K1,3-graphic sequences. Two characterizations of these imply two theorems due to Lai [11-12].

Inhibition of endothelial cell proliferation and angiogenesis is emerging as an important strategy in cancer therapeutics. Kringle 5 (K5) of human plasminogen is a potent angiogenesis inhibitor. Previous studies have shown K5 exposure promotes caspase activity and apoptosis in endothelial cells. Here we report that K5 treatment evokes an autophagic response in endothelial cells that is specific...

We give a computer-assisted proof of the fact that R(K5 − P3,K5) = 25. This solves one of the three remaining open cases in Hendry’s table, which listed the Ramsey numbers for pairs of graphs on 5 vertices. We find that there exist no (K5−P3,K5)-good graphs containing a K4 on 23 or 24 vertices, where a graph F is (G, H)-good if F does not contain G and the complement of F does not containH. The...

Breast cancer is characterized into different molecular subtypes, and each subtype is characterized by differential gene expression that are associated with distinct survival outcomes in patients. PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been shown to induce tumor heterogeneity and are associated with activation of EGFR-signa...

We had demonstrated that plasminogen kringle 5 (K5), a potent angiogenic inhibitor, inhibited retinal neovascularization and hepatocellular carcinoma growth by anti-angiogenesis. The current study investigated the effects and the underlying mechanisms of K5 on both tumor growth and spontaneous pulmonary metastasis in Lewis lung carcinoma (LLC) implanted mouse model. Similarly, K5 could decrease...

Kringle 5(K5) is the fifth kringle domain of human plasminogen and its anti-angiogenic activity is more potent than angiostatin that includes the first four kringle fragment of plasminogen. Our recent study demonstrated that K5 suppressed hepatocarcinoma growth by anti-angiogenesis. To find high efficacy and minimal peptide sequence required for the anti-angiogenic and anti-tumour activities of...

National Institute of Information and Communications Technology (NICT) has developed a new VLBI sampler unit named K5/VSSP32 dedicated to e-VLBI which is a successor to the K5/VSSP. The maximum sampling frequency per channel of the K5/VSSP32 is 64 MHz, which is four times as fast as that of K5/VSSP. In addition to the maximum sampling frequency, there is a difference in the interface to a host ...

BACKGROUND Identification of stem cells from a corneal epithelial cell population by specific molecular markers has been investigated previously. Expressions of P63, ABCG2 and K14/K5 have all been linked to mammalian corneal epithelial stem cells. Here we report on the limitations of K14/K5 as a limbal stem cell marker. METHODOLOGY/PRINCIPAL FINDINGS K14/K5 expression was measured by immunohi...