To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two diff...

OBJECTIVE To compare venous thrombosis rates among animals treated with aspirin, clopidogrel bisulfate, and ketorolac tromethamine using an anastomotic "tuck" model. DESIGN Single-blind randomized animal study. SETTING An animal laboratory at a tertiary care academic referral center. SUBJECTS Forty-two retired Lewis breeder rats divided into 3 equal groups. INTERVENTIONS Before surgical...

A reliable, rapid and sensitive isocratic reverse phase high-performance liquid chromatography method has been developed and validated for assay of ketorolac tromethamine in tablets and ophthalmic dosage forms using diclofenac sodium as an internal standard. An isocratic separation of ketorolac tromethamine was achieved on Oyster BDS (150×4.6 mm i.d., 5 μm particle size) column using mobile pha...

Effective pain management of the endodontic emergency patient is often a problem. Ketorolac tromethamine is the first nonsteroidal anti-inflammatory drug available for intramuscular injection in the United States. Although its analgesic efficacy is comparable with opiates after intramuscular injection, to date no study has evaluated its efficacy after intraoral periapical injection. Fifty-two e...

Purpose To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the beginning and end of cataract surgery following preoperative topical administration. Setting Santa Barbara Surgery Center, Santa Barbara, CA, USA. Design This was a pre-post, interventional, single-arm study. Patients and methods Patients undergoing cataract extraction and lens replacement (CEL...

Ketorolac tromethamine is a newly available non-steroidal anti-inflammatory drug which is suitable for parenteral administration. We have given it by continuous subcutaneous infusion to 36 patients with pain due to advanced cancer. Improvement in pain control occurred in 29 (80%). A reduction in the dose of concomitant opioid analgesia was possible in 22 (76%) and a reduction in opioid-related ...

T hank you for the opportunity to respond to the points put forth by the reader regarding the use of SPRIX ® (ketorolac tromethamine) nasal spray. As the developer of SPRIX ® , the reader points out that prior pharmacokinetic data comparing oral with intramuscular (IM) ketorolac indicate that the time for the drug to reach maximum plasma concentration (t max) is as low as 20 minutes in fasted i...

background: cataract extraction surgery remains the most commonly performed eye surgery by ophthalmologists. the maintenance of mydriasis is required throughout surgery to allow better visualization of the surgical field and a greater working space within the center of the eye. non-steroidal anti-inflammatory agents (nsaids) have their effect in maintaining mydriasis by their ability to inhibit...

ketorolac tromethamine (kt) containing microemulsion-based gels (mbgs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; epikuron 200) and oil (isopropyl myristate; ipm) and the effect of formulation variables on the release profile of the drug from mbgs through intact guinea pig skin and various artificial membr...