background: the hla class i molecules serve as ligands for both t cell receptors and killer cell immunoglobulin-like receptors (kirs). objective: we investigated the hlac and hla-bw4 alleles as well as kirs expression on cd56 positive lymphocytes to evaluate whether these genes and molecules could influence ankylosing spondylitis (as) susceptibility, alone or in combination. methods: we typed 4...

Somatic hypermutation in B cells is initiated by activation-induced cytidine deaminase-catalyzed C→U deamination at immunoglobulin variable regions. Here we investigate the role of the germinal centre-associated nuclear protein (GANP) in enhancing the access of activation-induced cytidine deaminase (AID) to immunoglobulin variable regions. We show that the nuclear export factor GANP is involved...

Submit Manuscript | http://medcraveonline.com Abbreviations: ANCA: Antineutrophil Cytoplasm Antibodies; BP: Blood Pressure; C: Complement; CD: Classification Determinant; CNC: Central Nervous System; CRP: C-Reactive Protein; CT: Computer Tomography; DNA: Deoxyribonucleic Acid; ECG: Electrocardiogram; ECHO-CG: Echocardiography; ESR: Erythrocytes Sedimentation Rate; Hb: Hemoglobin; HBs Ag: Hepati...

hepatitis b vaccination is safe and effective, although breakthrough infection occasionally occurs in those who receive the vaccine and hepatitis b immunoglobulin (hbig) prophylaxis. sequence variation in their antigenic regions is one of the most powerful strategies that are used by viruses to escape recognition by b and t cell-mediated immune responses. the aim of this study was to explore th...

An antibodylike paraprotein has been isolated from a patient with multiple myeloma and autoimmune hyperlipoproteinemia. The paraprotein bound to apolipoprotein B (apo B)-containing lipoproteins that formed macromolecular aggregates, and globules thought to be aggregated complexes of lipoproteins and reactive immunoglobulins were observed circulating within the retinal blood vessels of this pati...

Lymphoma occurs at increased frequency in patients with the acquired immunodeficiency syndrome (AIDS). We studied, using serologic and molecular techniques, one such lymphoma for (a) evidence of infection with human T lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b) monoclonal rearrangement of immunoglobulin and T cell receptor genes, and (c) rearrangement of the c-myc...

It has been found that the principal biochemical pathway activated in B cells stimulated by antigen- or anti-immunoglobulin-mediated crosslinking of surface immunoglobulin is that resulting in hydrolysis of phosphatidylinositol bisphosphate with generation of diacylglycerol and inositol trisphosphate. Recent evidence suggests that surface immunoglobulin-mediated B-cell activation can proceed wi...

Background—Many individuals have serum antibodies against Clostridium difficile toxins. Those with an impaired antitoxin response may be susceptible to recurrent, prolonged, or severe C diYcile diarrhoea and colitis. Aims—To examine whether treatment with intravenous immunoglobulin might be eVective in patients with severe pseudomembranous colitis unresponsive to standard antimicrobial therapy....