background and objective: evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. we have selected renal cell carcinoma (rcc) in this study. to determine tumor proliferative activity, ki67 antibody was applied and results were compared with apoptosis, applying p53 antib...

Department of Molecular, Cell and Cancer Biology 7 University of Massachusetts Medical School, Worcester, MA 01605, USA 8 9 Program in Bioinformatics and Integrative Biology 10 University of Massachusetts Medical School, Worcester, MA 01605, USA. 11 12 Program in Molecular Medicine 13 University of Massachusetts Medical School, Worcester, MA 01605, USA. 14 15 16 Running title: Ki-67 affects S p...

Background and Objective: The currentstudy aimed at investigating the histomorphological spectrum of cervical intraepithelial and invasive lesions assessing the diagnostic significance of P16/INK4a and Ki-67 in such lesions, andcorrelatingP16/INK4a and Ki-67 immunoexpression with histologic type and grade.Methods: A total of 60 cases were selectedcomprisi...

The primary purpose of this study was to evaluate the prognostic significance of Ki-67, a cell proliferation-associated antigen, in a large group (n = 674) of axillary node-negative breast cancer cases with long-term follow-up and to correlate Ki-67 antigen expression with S-phase fraction. Ki-67 immunostaining was assessed both semiquantitatively and quantitatively. The statistical analysis fo...

background and objectives: uterine smooth muscle tumors are the most common human neoplasm .they are divided clinically as benign and malignant but there is  another group of  lesions which is difficult to place in these two categories ,so-called smooth  muscle tumors of uncertain malignant potential (stump) and differentiation  of these tumors on the basis of h&e staining is impossible . t...