Due to age dependent organ manifestation, diagnosis of Marfan syndrome (MFS) is a challenge, especially in childhood. It is important to identify children at risk of MFS as soon as possible to direct those to appropriate treatment but also to avoid stigmatization due to false diagnosis. We published the Kid-Short Marfan Score (Kid-SMS) in 2012 to stratify the pre-test probability of MFS in chil...

The bacterial parD toxin-antitoxin system of plasmid R1 encodes two proteins, the Kid toxin and its cognate antitoxin, Kis. Kid cleaves RNA and inhibits protein synthesis and cell growth in Escherichia coli. Here, we show that Kid promotes RNA degradation and inhibition of protein synthesis in rabbit reticulocyte lysates. These new activities of the Kid toxin were counteracted by the Kis antito...

BACKGROUND The pediatric quality of life (QoL) questionnaire, the child-rated Kid-KINDL, has wording effects. However, no studies have examined for its parallel questionnaire, the parent-proxy Kid-KINDL. This study aimed to examine the psychometric properties and wording effects of the parent-proxy Kid-KINDL. METHODS Parents with 8- to 12-year-old children (n = 247) completed the parent-proxy...

Toward the end of mitosis, neighboring chromosomes gather closely to form a compact cluster. This is important for reassembling the nuclear envelope around the entire chromosome mass but not individual chromosomes. By analyzing mice and cultured cells lacking the expression of chromokinesin Kid/kinesin-10, we show that Kid localizes to the boundaries of anaphase and telophase chromosomes and co...

Gary Becker's \Rotten Kid Theorem" asserts that if all family members receive gifts of money income from a benevolent household member, then even if the household head does not precommit to an incentive plan for family members, it will be in the interest of sel sh family members to maximize total family income. We show by examples that the Rotten Kid theorem is not true without assuming transfe...

A study to evaluate the reproductive performance of Abergelle goat was carried out at Sekota District of Amhara National Regional State. On-farm flocks from two peasant associations were monitored for two years to collect data. Data collected included identification number of doe and kid, birth / kidding date, kid birth weight, sex of kid, post partum doe weight, litter size, parity of doe. Dat...

The human chromokinesin Kid/kinesin-10, a plus end-directed microtubule (MT)-based motor with both microtubule- and DNA-binding domains, is required for proper chromosome alignment at the metaphase plate. Here, we performed RNA interference experiments to deplete endogenous Kid from HeLa cells and confirmed defects in metaphase chromosome arm alignment in Kid-depleted cells. In addition, we not...

The use of computers is increasing in mathematics education. This trend is supported by the NCTM standards and computational power applicable in mathematical curricula. As part of CAI software, Linear Kid was designed, developed and evaluated reflecting upon NCTM standards. Linear Kid is a computer-based peer tutoring system where students become active learners who are guided to learn by teach...

Measurement invariance is an important assumption to meaningfully compare children's quality of life (QoL) between different raters (eg, children and parents) and across genders. Moreover, QoL instruments may combine using negatively and positively worded items-a common method to reduce response bias. However, the wording effects may have different levels of impact on different raters and gende...

Is overall performance of an AI-based embryo evaluation model improved by including discarded embryos during training compared to using only transferred with known implantation data (KID)? A set 14,643 KID fetal heart (4,337 FH+ and 10,307 FH-) incubated for at least 4 days was obtained from 18 different clinics. The also included 23,674 either cryopreserved or unknown FH 101,153 that were thus...