The paper describes overt marking of information structure in the indigenous Andean language Aymara. In this paper we show that although the word order is free, Aymara is not a discourse-configurational language (Kiss, 1994); instead, information structure is expressed only morphologically by pragmatic suffixes. The marking of ‘topic’ is more flexible that the marking of ‘focus’ (be it at the c...

We introduce the MathGR package, written in Mathematica. The package can manipulate tensor and GR calculations with either abstract or explicit indices, simplify tensors with permutational symmetries, decompose tensors from abstract indices to partially or completely explicit indices and convert partial derivatives into total derivatives. Frequently used GR tensors and a model of FRW universe w...

BACKGROUND Recurrence and metastasis are the usual manifestations of treatment failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predicti...

The expression of KiSS-1, MMP-9 and MMP-2 mRNAs and proteins was studied in placentas of women with preeclampsia (PE, n=47) and women of normal pregnancy (NP; n=30). In addition, KiSS-1 mRNA expression as well as cell growth, proliferation and invasion were examined in JAR cells (human trophoblast cell line) transfected with pcDNA3-KiSS-1vector. Expression of KiSS-1 mRNA and protein was higher ...

Purpose KiSS-1 and its product, kisspeptin is necessary for pubertal onset and proper adult gonadal function due to its stimulatory effect on the secretion of gonadotropinreleasing hormone (GnRH). Although the pathophysiological importance of KiSS-1 and kisspeptin is well known, the developmental patterns of expression of KiSS-1 genes and serum level of kisspeptin have not been explored to date...

Methods A surveillance module for multidrug resistant bacteria (MDR-KISS) was added to ICU-KISS in 2006. Participating ICUs report data on patients with MRSA, VRE and ESBL bacteria. In contrast to ICU-KISS on nosocomial infections, MDR-KISS documents cases of MDR bacteria including colonization and infection present on admission. MDR-KISS collects the following data: date of ICU-admission and I...

The gonadotropic axis is centrally controlled by a complex regulatory network of excitatory and inhibitory signals that is activated at puberty. Recently, loss of function mutations of the gene encoding G protein-coupled receptor 54 (GPR54), the putative receptor for the KiSS-1-derived peptide metastin, have been associated with lack of puberty onset and hypogonadotropic hypogonadism. Yet the p...

The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined whether estradiol (E2) regulates KiSS-1 in the forebrain of the female mouse by comparing KiSS-1 mRNA expression among groups of ovary-intact (diestrus), ovariectomized (OVX), and OVX plus E...

Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that occurred in early vertebrates. This review examines compelling r...