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تعداد نتایج: 16 فیلتر نتایج به سال:
The designed peptide pyridine-2-carboxamidonetropsin (2-PyN) binds to the minor groove of double-helical DNA at two very different sequences, 5’-TTTTT-3’ and 5’-TGTCA-3’, with comparable energetics but quite different structures. 2-PyN likely binds the 5’-TTTTT-3’ site as a 1:l complex, whereas 2-PyN binds 5’-TGTCA-3’ sites as a 2:l complex. In order to enhance the binding affinity of 2-PyN for...
Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus (L.) G.Don is a rich source of plant-derived medicinal terpenoid indole alkaloids (TIAs), including the anti-hypertensive ajmalicine, the sedative compound serpentine, and the anticancer drugs vinblastine and vincristine. However, the latter two compounds are produced in C. roseus plants only in very low amounts. Elicitor...
Introduction: Due to the large number of accidents in Iran, infants need the rapid transport to the hospitals. Air transport is the fastest way to arrive these centers. There are differences in trauma management between infants and adults because of their different physiology and anatomy. This study aimed to survey air transport of traumatic infants. Methods and Materials: This research is a r...
Paleotopographic reconstructions of the eastern outlets of glacial Lake Agassiz provide a foundation for understanding the complex manner in which terrain morphology controlled the routing of overflow through the eastern outlets during the lake's Nipigon Phase (ca. 9400-8000 ''^C years BP) and for understanding the causes of outlet-driven declines in lake level during that period. Although flow...
An 4 1/ 4 7 dual antagonist, S-compound 1, was used as a model ligand to study the effect of divalent cations on the activation state and ligand binding properties of 4 integrins. In the presence of 1 mM each Ca /Mg , S-compound 1 bound to several cell lines expressing both 4 1 and 4 7, but 2S-[(1-benzenesulfonyl-pyrrolidine-2S-carbonyl)-amino]-4-[4methyl-2S-(methyl-{2-[4-(3-o-tolyl-ureido)-phe...
Selective placement of an aliphatic â-alanine (â) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects for recognition of the minor groove of DNA by hairpin pyrrole-imidazole polyamides. A series of polyamides were prepared which contain pyrrole and imidazole aromatic amino acids, as well as γ-aminob...
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