The crystal structure of the orthorhombic phase of L-cysteine (hereafter L-cysteine-I) consists of chains of molecules linked via NH...O hydrogen bonds. The chains are linked into a layer by other NH...O hydrogen bonds, forming R4(4)(16) ring motifs. The layers are linked by further NH...O and disordered SH...S/SH...O interactions. The main effects of compression to 1.8 GPa are to contract void...

BACKGROUND Escherichia coli has two L-cysteine biosynthetic pathways; one is synthesized from O-acetyl L-serine (OAS) and sulfate by L-cysteine synthase (CysK), and another is produced via S-sulfocysteine (SSC) from OAS and thiosulfate by SSC synthase (CysM). SSC is converted into L-cysteine and sulfite by an uncharacterized reaction. As thioredoxins (Trx1 and Trx2) and glutaredoxins (Grx1, Grx...

In this study, a sensing device employing gold-coated quartz tuning fork (QTF) modified with self-assembled monolayer (SAM) of L-cysteine was evaluated for the sensitive detection Cu2+ ions in aqueous solutions. Three copper (II) salts, CuSO4, CuCl2, and Cu(NO3)2, at four different concentrations (10−12, 10−10, 10−8, 10−6 M) small (100 μL) water sample amounts were each used as analytes to inve...

Medical literature indicates clearly that cystinuria and cystinosis, two severe genetic pathologies, are related to the presence of abnormal L-cystine deposits. While adopts a hexagonal crystal morphology consistent with its crystallographic structure (hexagonal, P6 1 22 space group), deposits cystinosis display rectangular shape. Because this is unexpected from L-cystine, we have investigated ...

Continuous improvements of cell culture media are required in order to ensure high yield and product quality. However, some components can be instable lead detrimental effects on bioprocess performances. l-cysteine is an essential amino acid commonly used media. Despite its beneficial effect recombinant protein production, cases, this component responsible for microheterogeneity. In context, al...

Organisms that overproduced L-cysteine and L-cystine from glucose were constructed by using Escherichia coli K-12 strains. cysE genes coding for altered serine acetyltransferase, which was genetically desensitized to feedback inhibition by L-cysteine, were constructed by replacing the methionine residue at position 256 of the serine acetyltransferase protein with 19 other amino acid residues or...

OBJECTIVE This study was performed to determine the effect of N-acetyl-L-cysteine, a modified sulfur-containing amino acid that acts as a strong cellular antioxidant, on the response to environmental stressors and on aging in C. elegans. METHOD The survival of worms under oxidative stress conditions induced by paraquat was evaluated with and without in vivo N-acetyl-L-cysteine treatment. The ...