MicroRNAs (miRNAs) have been suggested to play important roles in cell proliferation, apoptosis, and differentiation. In this study, we examined miRNA expression profiles during 3T3-L1 pre-adipocyte differentiation. We constructed miRNA libraries from pre- and post-differentiated 3T3-L1 cells, and identified the expression of 77 previously reported miRNAs and 3 new miRNAs. Next, we investigated...

The characteristic peaks (pre-edge peaks) in the La L1-edge X-ray absorption near edge structure (XANES) of various La complex oxides were analyzed by both experimental and theoretical approaches. The pre-edge peak areas are correlated with the bond angle analysis (BAA) parameter, which we proposed as an indicator of the centrosymmetry or disorder of the local configuration of the La site. The ...

Each half of the medulla contains respiratory neurons that constitute two generators that control respiratory rhythm. One generator consists of the inspiratory neurons in the pre-Bötzinger complex (preBötC); the other, the pre-inspiratory (Pre-I) neurons in the parafacial respiratory group (pFRG), rostral to the preBötC. We investigated the contribution of the commissural fibers, connecting the...

The current study investigated the effects of oral code-mixing and glossing on L2 vocabulary learning. To this end, 60 EFL learners studying at pre-university school were given a pre-test to make sure that they did not have any prior knowledge of the target words. Based on their scores in the pre-test, 36 pre-university students were selected and divided into three groups, including two experim...

PURPOSE To evaluate the expression of tumor PD-L1 and changes in tumor-infiltrating lymphocyte (TIL) populations in patients with metastatic melanoma treated with targeted MAPK inhibitors. EXPERIMENTAL DESIGN Ninety-three tumors were analyzed from 40 patients treated with a BRAF inhibitor alone (BRAFi; n = 28) or combination of BRAF and MEK inhibitors (Combi; n = 12). Tumors were excised befo...

The impact of serum levels of soluble programmed cell death ligand 1 (sPD-L1) on prognosis in patients with Epstein-Barr virus-associated malignancies has never been investigated. We prospectively measured pre- and post-treatment serum sPD-L1 levels and evaluated their prognostic value in 97 patients with newly diagnosed, early stage extranodal NK/T-cell lymphoma (ENKTCL) treated with asparagin...

Efficacy of Enzalutamide (ENZ) in castration resistant prostate cancer (CRPC) patients is short-lived. Immunotherapy like T cell checkpoint blockade may improve patient survival. However, when and where checkpoint molecules are expressed in CRPC and whether immune evasion is a mechanism of ENZ resistance remains unclear. Thus, we investigated whether clinically relevant immunotherapy targets, s...

Objective: DLBS3233 is a standardized extract combination containing Lagerstroemia speciosa and Cinnamomum burmannii. The effect of DLBS3233 on adipocyte differentiation was examined in this study. Methods: 3T3-L1 pre-adipocyte was used to investigate gene expression using the real-time reverse transcription polymerase chain reaction (RTPCR) method. Oil red-O staining for detecting lipid format...

26 Each half of the medulla contains respiratory neurons which compose two 27 generators that control respiratory rhythm. One generator consists of the inspiratory 28 neurons in the preBötzinger Complex (preBötC); the other of the preinspiratory (Pre-I) 29 neurons in parafacial respiratory group (pFRG) rostral to the preBötC. We investigated 30 the contribution of the commissural fibers connect...