A label-free electrochemical nucleic acid aptasensor for the detection of methamphetamine (MA) by the immobilization of thiolated self-assembled DNA sequences on a gold nanoparticles-chitosan modified electrode is constructed. When MA was complexed specifically to the aptamer, the configuration of the nucleic acid aptamer switched to a locked structure and the interface of the biosensor changed...

In food sector, there is a huge demand for rapid, reliable, user & eco-friendly biosensors to analyse the quality and safety of food products. Biosensor based methodology depends upon the recognition of a specific antigens or receptors by corresponding antibodies, aptamers or high-affinity ligands. The first scientifically commercialised sensors were the electrochemical sensors used for the ana...

let $g=(v‎, ‎e)$ be a graph with $p$ vertices and $q$ edges‎. ‎an emph{acyclic‎ ‎graphoidal cover} of $g$ is a collection $psi$ of paths in $g$‎ ‎which are internally-disjoint and cover each edge of the graph‎ ‎exactly once‎. ‎let $f‎: ‎vrightarrow {1‎, ‎2‎, ‎ldots‎, ‎p}$ be a bijective‎ ‎labeling of the vertices of $g$‎. ‎let $uparrow!g_f$ be the‎ ‎directed graph obtained by orienting the...

Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed interest. However, owing to the intrinsic com...

Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules....