To investigate the possible biological function of the lateral "strand dimer" observed in crystal structures of a D1 domain extracellular fragment from N-cadherin, we have undertaken site-directed mutagenesis studies of this molecule. Mutation of most residues important in the strand dimer interface abolish the ability of N-cadherin to mediate cell adhesion. Mutation of an analogous central res...

Dear Editor: In a recent issue of this journal (vol. 40, issue No. 1, pp. vii–ix), Alexander Dromerick, MD, contributed an editorial on " Evidence-based rehabilitation: The case for and against constraint-induced movement therapy. " We strongly endorse the first part of the editorial that speaks to the importance of basing clinical practice in neurorehabilita-tion on a solid foundation of exper...

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Clin Med 1985;106:30–7. 2. College of American Pathologists 2006 participant survey for hemoglobin A electrophoresis. Northfield (IL): College of American Pathologists; 2006. 3. Hydragel 7 & 15 Hemoglobin(e) [package insert]. Norcross (GA): Sebia; 2006/09. 4. Helena procedural package inserts page. Helena Laboratories Website. Available at: http:// www.helena.com/Procedures/Pro015%20Rev6. pdf. ...

Commercial LIMS have been available for more than 20 years and have become key elements in the laboratory informatics framework. During these years there have been many changes within the LIMS industry, many of them driven by rapidly developing technologies. At the same time, evolving business requirements and pressures have been crucial factors in making LIMS the sophisticated business-critica...

Gale crater formed from an impact on Mars *3.6 billion years ago. It hosts a central mound nearly 100 km wide and *5 km high, consisting of layered rocks with a variety of textures and spectral properties. The oldest exposed layers contain variably hydrated sulphates and smectite clay minerals, implying an aqueous origin, whereas the younger layers higher on themound are covered by amantle of d...