The hydrolytic degradation of oriented poly(L-lactide-co-glycolide) 85 L/15 G (PLGA 85/15) sample materials with various amounts of lactide monomer was monitored in vitro at 37 °C. The materials were manufactured from medical grade PLGA 85/15 by a two-step melt extrusion-die drawing process. Results showed that the hydrolytic degradation rate depended highly on the lactide monomer content, whic...

in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

New sterically encumbered N-heterocyclic carbene catalysts were synthesized and used to polymerize rac-lactide to give highly isotactic polylactide or meso-lactide to give heterotactic polylactide.

The simultaneous improvement of the melting temperature (T(m) = 224 °C) and the decomposition temperature (T(10) = 359 °C) of poly(lactide)s was achieved by the stereocomplex formation of poly(l-lactide) and poly(d-lactide) with bio-based aromatic groups at both initiating and terminating chain ends.

Abstract In this study, poly-lactic acid (PLA) and poly-3-hydroxybutyrate- co -3-hydroxyhexanoate (PHBH) were pyrolyzed at various temperatures (300, 350, 400, 500, 600, 700 °C) heating rates (5, 10, 20, 30, 40 °C min −1 ) using a pyrolysis–gas chromatograph/mass spectrometer (Py–GC/MS). The results revealed that the main pyrolysis products of PLA acetaldehyde, lactide (including meso-lactide d...

Two binuclear magnesium and zinc alkoxides supported by a bis-salalen type dinucleating heptadentate Schiff base ligand were synthesized and fully characterized. The two complexes are efficient initiators for the ring-opening polymerization (ROP) of L-lactide, affording polymers with narrow polydispersities and desirable molecular weights. Interestingly, the mechanisms for the ROP of lactide ar...

Polyesters, especially poly(lactide) (PLA), are used widely as biodegradable and biocompatible materials, yet their controllable synthesis, especially the stereoselective synthesis of polyesters, is still a challenge. Recently some excellent Lewis pair catalysts for ring-opening polymerization (ROP) of lactide and related cyclic esters have emerged. This review article will highlight the key ad...

Abstract Ring‐opening polymerizations (ROP) of l ‐lactide (LA) are conducted in bulk at 130, 160, or 180 °C and initiated with two different alcohols 160 °C. The lactide/initiator ratio (LA/In) is varied from 50/1 (20/1 °C) to 900/1 the lactide/catalyst (LA/Cat) between 2000/1 8000/1. At all temperatures a nearly perfect control number average molecular weight ( M n ) via LA/In feasible up = 20...

Electrospinning is a long-known polymer processing technique that has received more interest and attention in recent years due to its versatility and potential use in the field of biomedical research. The fabrication of three-dimensional (3D) electrospun matrices for drug delivery and tissue engineering is of particular interest. In the present study, we identified optimal conditions to generat...

PLA is one of the most promising bio-compostable and bio-degradable thermoplastic polymers made from renewable sources. PLA is generally produced by ring opening polymerization (ROP) of lactide using the metallic/bimetallic catalyst (Sn, Zn, and Al) or other organic catalysts in a suitable solvent. In this work, reactive extrusion experiments using stannous octoate Sn(Oct)2 and tri-phenyl phosp...