نتایج جستجو برای: lamotrigine monotherapy
تعداد نتایج: 16820 فیلتر نتایج به سال:
OBJECTIVES To identify adverse drug reactions associated with lamotrigine in children and compare the safety profile with other antiepileptic drugs. SETTING Databases EMBASE (1974-April 2015), MEDLINE (1946-April 2015), PubMed and the Cochrane library for randomised controlled trials were searched for studies on safety of lamotrigine. PARTICIPANTS All studies involving paediatric patients a...
Keynote address: " Marfan syndrome and related disorders: from gene to therapy " Prof. 3 AED Pregnancy register, UK and Ireland Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The risk magnitude varies by AED exposure. We provide results from the UK and Ireland Epilepsy and Pregnancy Registers, of the risk of MCMs after monotherapy...
OBJECTIVE To test previous signals of a risk of orofacial cleft (OC) and clubfoot with exposure to the antiepileptic lamotrigine, and to investigate risk of other congenital anomalies (CA). METHODS This was a population-based case-malformed control study based on 21 EUROCAT CA registries covering 10.1 million births (1995-2011), including births to 2005 in which the clubfoot signal was genera...
PURPOSE The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. METHODS Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, 9.1±3.4 years) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before tre...
Lamotrigine is frequently used to manage epilepsy during pregnancy. However, some major and minor birth defects are reported with lamotrigine monotherapy. This study is a case series report on 20 epileptic women who were receiving lamotrigine in their pregnancy. Apart from the normal pregnancies and births, in our study three patients gave birth to healthy twins, two vanished twin syndromes occ...
OBJECTIVE To determine the frequency of malformations among infants born to women who had taken lamotrigine or carbamazepine as part of polytherapy during the first trimester of pregnancy. DESIGN A cohort of women enrolled during pregnancy in the North American AED (Antiepileptic Drug) Pregnancy Registry between February 1, 1997, and June 1, 2010. Information on AED use and demographic charac...
QUESTION One of my female patients has epilepsy and is currently receiving lamotrigine monotherapy. She has recently found that she is 6 weeks pregnant and is concerned about possible side effects of lamotrigine on her fetus. How should I advise her and should I switch to another antiepileptic drug? ANSWER Lamotrigine (LTG) has not been associated with an increased risk for major malformation...
Ulster Medical Society Junior Members Forum Thursday 12th December 2013 Whitla Medical Building, Queen’s University Belfast. ASPIRIN THERAPY IS ASSOCIATED WITH REDUCED MORTALITY IN PATIENTS WITH ACUTE LUNG INJURY Boyle AJ, Digangi A, Mottram LJ, Hamid U, McNamee L, White G, Cross LJM, McNamee J, O’Kane C, McAuley DM. Introduction: Platelet activation has a role in the pathogenesis of acute lung...
The full effects of lamotrigine on photo and pattern sensitivity have never been fully studied, although there is some small indication in the literature of a possible beneficial effect. It is the policy of Birmingham Brainwave to substitute lamotrigine for valproate in young women who wish to become pregnant, who have primary generalized epilepsy: we use it as first-line monotherapy in young w...
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