www.thelancet.com Published online March 23, 2016 http://dx.doi.org/10.1016/S0140-6736(16)00165-3 1 WHO’s goals for tuberculosis c ontrol after 2015 are to reduce the number of deaths by 95% and the number of new cases by 90% by 2035. These ambitious goals will require development of new approaches for preventing emergence of active tuberculosis from the vast pool of individuals with latent tub...

Active tuberculosis (TB) in the UK predominantly affects the non-UK born, but is generally not manifest at the time of UK entry. Strategies to detect latent TB infection (LTBI) in this population are, therefore, important. To date, targeted screening has focused on TB risk estimates based on the incidence in the country of origin. Using TB incidence in the UK and migration data, we estimated th...

BACKGROUND The majority of tuberculosis in migrants to Canada occurs due to reactivation of latent TB infection. Risk of tuberculosis in those with latent tuberculosis infection can be significantly reduced with treatment. Presently, only 2.4% of new migrants are flagged for post-landing surveillance, which may include latent tuberculosis infection screening; no other migrants receive routine l...

it is assumed that about 10% of individuals infected with mycobacterium tuberculosis develop tuberculosis. the rate of tuberculosis in solid organ transplant recipients has been estimated to be 50-fold higher than in the general population. candidates for solid organ transplantation are routinely screened for latent tuberculosis infection (ltbi). in this study we aimed to compare tuberculin ski...

BACKGROUND Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may allow discrimination between active tuberculosis and latent tuberculosis infection. METHODS A prospective comparison of M. tuberculosis-specific cellular immunity in subjects with active tuberculosis and latent tuberculosi...

background tubercle bacilli most often are transmitted from one person by the airborne route. the aim of the present study was to determine the frequency of latent tuberculosis infection and active pulmonary tuberculosis among patients with chronic psychiatric disorders in hamedan. patients and methods in a cross sectional study, 215 patients with chronic psychiatric disorders were investigated...

It is estimated that one third of the world's population have latent tuberculosis infection and that this is a significant reservoir for future tuberculosis cases. Most cases occur within two years following initial infection. The identification of individuals with latent tuberculosis infection is difficult due to the lack of an ideal diagnostic assay and incomplete understanding of latent infe...

During tuberculosis, macrophages are critical for both pathogen survival and host immune activation. Since expression of particular cell surface markers reflects cell function, we used flow cytometry to measure the abundance of surface markers associated with polarity, lipid uptake, or pattern recognition on macrophages found in induced sputum. Nine macrophage surface markers were examined from...

Background. Biomarkers to distinguish latent from active Mycobacterium (M.) tuberculosis infection in clinical practice are lacking. The urinary neopterin/creatinine ratio can quantify the systemic interferon-gamma effect in patients with M. tuberculosis infection. Methods. In a prospective observational study, urinary neopterin levels were measured by enzyme linked immunosorbent assay in patie...