The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substa...

Objetivo: establecer diferencias metabólicas entre pacientes con LA e individuos sanos (IS) mediante LC/GC-QTOF-MS. Metodología: posterior a la firma del formato de consentimiento informado, se recolectaron muestras plasma 20 diagnóstico (incluyendo leucemia mieloides y linfoides) servicio Hematología Hospital Universitario San Ignacio IS. El metaboloma el lipidoma en fue evaluado por análisis ...

An overview is given on mass spectrometry-based metabolomics: past, current, and future developments. Understanding the metabolome is challenging due to the enormous diversity of metabolite structures. Metabolomics uses a range of tools, established as service at the NIH West Coast Metabolomics Center at UC Davis. We here explore the use of ion mobility spectrometry (IMS) in combination with li...

Salak (Salacca zalacca) is well-known as snake fruit and it immensely studied for its antioxidative antidiabetic active metabolites throughout the southeast Asian countries. However, there are many remaining unidentified due to very low abundance natural variation, which need be further explored. Nowadays mass spectrometry (MS/MS) facilitates tentative identification of unknown compounds in cru...

The analytical capabilities of various liquid chromatography/mass spectrometry (LC/MS) instruments are compared in the study of illicit and prescription drugs in blood. The blood samples analyzed include postmortem and driving under the influence of drugs (DUID). The presence of drug compounds in these samples was previously confirmed using gas chromatography/mass spectrometry (GC/MS). In this ...

A library of collision-induced dissociation (CID) accurate mass spectra has been developed for efficient use of liquid chromatography in combination with hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) as a tool in systematic toxicological analysis. The mass spectra (Δm < 3 ppm) of more than 2,500 illegal and therapeutic drugs, pesticides, alkaloids, other toxic chemicals and me...

The identification and determination of transformation products (TPs) of pharmaceuticals is essential nowadays, in order to track their fate in the aqueous environment and, thus, to estimate the actual pollution. However, this is a challenging task due to the necessity to apply high-resolution instruments enable to detect known and unknown compounds. This work presents the use of liquid chromat...

Aqueous humor (AH) is a transparent fluid which fills the anterior and posterior chambers of the eye. It supplies nutrients and removes metabolic waste from avascular tissues in the eye. Proper homeostasis of AH is required to maintain adequate intraocular pressure as well as optical and refractive properties of the eye. Application of metabolomics to study human AH may improve knowledge about ...