the purpose of this study was to investigate the hypothesis weather the combination of lead acetate and deltamethrin can enhance avian toxic effects produced by lead exposure only. overall, 48 japanese quails, coturnix coturnix japonica (15 day old) were randomly divided into 4 experimental groups of 12 birds each and sex ratio of 1:1. experimental groups consisted of control japanese quails, b...

chronic exposure to lead (pb) affects neural functions in central nervous system (cns) particularly the learning and memory. on the other hand, alteration of calcium level in the cns results in activation of nos. it has been shown that lead enters the neurons through calcium channels and displaces ca2+ from calcium binding proteins such as calmodulin and troponin c thereby affecting calcium-med...

lead is an ubiquitous environmental toxin that induces a broad range of physiological biochemical, and behavioral dysfunctions. in this study, we examined the pathologic effects of lead acetate in nmri mouse ovarian tissue and the protective role of antioxidant l-cysteine, against the induced damage. we used lead acetate at a dose of 10 mg/kg, and l-cysteine at a dose of 200 mg/kg. both drugs w...

Background. T cell mediated inflammation contributes to atherogenesis and the onset of acute cardiovascular disease. Effector T cell functions are under a tight control of a specialized T cell subset, regulatory T cells (Treg). At present, nothing is known about the in situ presence of Treg in human atherosclerotic tissue. In the present study we investigated the frequency of naturally occurrin...

  In this study interaction of three types of calcium channel blockers nifedipine, diltiazem and verapamil on the effects of lead acetate on two types of pain (nociception and inflammation) induced by formalin in mice were examined. In order to study nociception, formalin test was selected because of greater resemblance to clinical pain. Lead acetate (50, 75, l00, 125 and 150 mg/kg) administere...

Lead acetate trihydrate (PbA) was evaluated in this follow-up study as a possible reproductive toxicant using the RACB protocol (Morrissey et al., Fundam Appl Toxicol 13:747-777 [1989]). A previous study at the other RACB laboratory found significant toxicity at concentrations in the drinking water greater than or equal to 0.5%. Thus, levels for this study were set at 0.125, 0.25, and 0.5% weig...

lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. also, epileptic type convulsion is a known complication of hypothyroidism. this study was performed to determine the effect of propylthiouracil (ptu)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (ptz)-induced kindling parameters. the test was carried out by using male albino r...