Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural p...

Lead optimisation is a defining point in a drug discovery project. To this point, time and resources have been dedicated to virtual and in vitro screening to identify a chemical space that fits predefined project requirements. Requirements include affinity towards the target at dose responsive concentrations in the low (M range); freedom from intellectual property; chemical tractability; reason...

Lead belongs to the group of blood poisons that impair synthesis porphyrins and heme. Under industrial conditions, only chronic lead poisoning can develop. have effect material cumulation. The half-life is 20 years. Once in body, it deposited many organs form insoluble tribasic phosphates. A significant part trabeculae bones. influence provoking factors, an intensive release from depot be obser...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...