A.1.) Leishmania major sphingolipids and ethanolamine lipids ......................................... 3 A.1.a.) Sphingolipids are essential for differentiation but not growth in Leishmania .................... 3 A.1.b.) Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. ....................................................................

Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice highly susceptible to L. challenge due their inability mount parasite-dependent IFN-γ-mediated responses. Here, we analyzed capacity a single administration LiΔHSP70-II genetically-modified attenuated infantum line preventing challenged with virulent parasites. In previous studies, t...

Plasmodium falciparum Amebae (Intestinal) Babesia species Entamoeba histolytica Flagellates (Leishmaniae, Trypanosomes) Entamoeba dispar* Leishmania tropica complex Entamoeba hartmanni Leishmania mexicana complex Entamoeba coli Leishmania braziliensis complex Entamoeba polecki Leishmania donovani complex Endolimax nana Leishmania peruviana Iodamoeba bütschlii Trypanosoma brucei gambiense Blasto...

BACKGROUND Autochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients. METHODS A cross-sectional study was conducted to determine the prevalence...

Leishmania spp. are polarized single-celled eukaryotic parasites, the perpetuation of which relies on two other organisms they "use" as hosts. One of the Leishmania host organisms is a blood-feeding female sand fly, the second host being a mammal that acts as a blood source for the female sand fly. Leishmania-hosting sand flies transmit the metacyclic promastigote developmental stage to the mam...

OBJECTIVES This study was performed to investigate the activity of tamoxifen, an antioestrogen widely used in the treatment of breast cancer, against Leishmania. METHODS Drug activity was assessed in vitro against axenically grown promastigotes and amastigotes through cell counting or by measuring the cleavage of MTT, and against intracellular amastigotes by treating infected macrophage cultu...

A leishmaniose é uma zoonose causada por um protozoário do reino Protista gênero Leishmania. É problema de saúde pública com prognóstico desfavorável para animais contaminados. cidade Unaí – MG no noroeste mineiro considerada área endêmica da enfermidade, grande casuística em e humanos. Foi atendido cão queixa prolapso retal; porém, após investigação clínica averiguou-se a presença seborreia, l...

The detection and identification of natural infections in sand flies by Leishmania protozoan species in endemic areas is a key factor in assessing the risk of leishmaniasis and in designing prevention and control measures for this infectious disease. In this study, we analyzed the Leishmania DNA using nuclear ribosomal internal transcript spacer (ITS) sequences. Parasite DNA was extracted from ...