In view of the results obtained in animal experiments we have studied clinically the effects of administering partially purified gametic extracts to elderly patients with opacity of the lens. Out of 12 patients treated orally or parenterally 10 have shown, on subjective and objective evaluation, a significant increase in vision, a clearing of the opacity of the lens, and an improvement of gener...

Materials and methods This was an exploratory cross-sectional study, carried out at the Outpatient Clinics of Nutrition and Ophthalmology at the Federal University of Bahia, Salvador-Bahia, Brazil. Seventy eight patients, of both genders, with age-related cataract, participated. All patients underwent nutritional, clinical and ophthalmological assessment. Type of lens opacity was determined fol...

OBJECTIVE To use dynamic light scattering to clinically assess early precataractous lens protein changes. METHODS We performed a cross-sectional study in 380 eyes of 235 patients aged 7 to 86 years with Age-Related Eye Disease Study clinical nuclear lens opacity grades 0 to 3.8. A dynamic light-scattering device was used to assess alpha-crystallin, a molecular chaperone protein shown to bind ...

The purposes of this study were to assess the expression patterns of heat shock proteins (Hsps), after eyeball heating or cooling, and to elucidate their relationships with corneal wound healing and intraocular complications after excimer laser treatment. Experimental mice were grouped into three according to local pretreatment type: heating, cooling, and control groups. The preconditioning was...

The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Ch...

PURPOSE To study the relationships between the refractive power of the crystalline lens, overall refractive error of the eye, and degree of nuclear cataract. METHODS All phakic participants of the population-based Central India Eye and Medical Study with an age of 50+ years were included. Calculation of the refractive lens power was based on distance noncycloplegic refractive error, corneal r...

PURPOSE To investigate modifications of ocular surface and lens transparency in patients with cystic fibrosis in relation to the stage of digestive insufficiency. METHODS Forty consecutive patients with cystic fibrosis and 24 age- and sex-matched healthy volunteers were examined. The tear tests (Schirmer's basic test, tear film break-up time) and conjunctival exfoliative cytology (CC) were us...

Purpose: To evaluate efficacy, predictability and safety of the surgical correction of high myopia using the phakic posterior chamber implantable collamer lens. Design: A prospective, nonrandomized, non-comparative interventional case series. Participants: Twenty seven eyes of fifteen patients aged from 20 to 46 years having high myopia were included. Intervention: STAAR modified collamer impla...

OBJECTIVE To investigate the association between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and cataract in a metropolitan Asian elderly population. DESIGN Population-based cross-sectional study. Age-related cataract was defined as any type of lens opacity (ie, nuclear, cortical, and posterior subcapsular opacity) with a Lens Opacities ...

BACKGROUND Data suggest a possible protective effect against lens opacity with use of hormone replacement therapy (HRT). However, no agreement exists on which opacity type is affected, and more exploration of the additional role of endogenous estrogen exposure is warranted. OBJECTIVE To determine whether HRT and the prevalence of different lens opacity types are associated after controlling f...