The skin is a unique marker for malignancy as these cutaneous manifestation not only often precede the development of other symptoms, but also often cause patients to seek medical attention sooner than they would for other symptoms. Common cutaneous markers for malignancy include: acanthosis nigricans, carcinoid syndrome, Leser-Trelat sign, and necrolytic migratory erythema. Although these skin...

florid cutaneous papillomatosis (fcp), is a rare cutaneous marker of internal malignancy. the underlying cancer is usually intra-abdominal (most often gastric in origin), and evolves parallel to the fcp. there is a common association between fcp and the other two eruptive paraneoplastic syndromes, i.e.malignant acanthosis nigricans and the sign of leser-trelat. it seems possible that these synd...

Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses in association with underlying malignant disease. A case of Leser-Trélat sign in a 66-year-old healthy woman is presented. Evaluation and follow-up for the development of malignancy over a 2-year period failed to reveal any evidence of malignancy. To date, almost all cases of Leser-Trélat sign have been...