Chronic dopamine replacement therapy in Parkinson’s disease (PD) leads to deleterious motor sequelae known as L-DOPAinduced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [( )propranolol], a nonselective -adrenergic receptor ( AR) antagonist, may reduce LID. The present study used the rat unilater...

This study provides a comprehensive description of upper eyelid movement in normal human subjects. Using the magnetic search coil technique to monitor lid position and modified skin electrodes to record orbicularis oculi electromyographic (EMG) activity, the authors found that the basic eyelid movements, blinks, and saccadic lid movements, can be uniquely and reliably characterized by their amp...

PARADOXICAL lid retraction of the ptotic lid on occlusion of the sound eye and several other synkinetic oculopalpebral phenomena are described in the literature in relation to ophthalmoplegia, congenital as well as acquired (Lewallen, 1958; Walsh, 1957). Fuchs's phenomenon of lid retraction on lateral movement, the pseudo-Graefe phenomenon with depression and lid retraction on elevation, are al...

Case Age at Cause of No. Onset Sex Ophthalmoplegia Manifestation (yrs) 1 47 F S u b a r a c h no i d !Fuchs's phenomenon of lid retraction on adduction haemorrhage Pseudo-Graefe phenomenon of lid retraction on looking down 2 i F Typhoid Paradoxical retraction on occlusion of sound eye 3 5 M Head injury Lid retraction on attempted adduction Pseudo-Graefe phenomenon of lid retraction on looking d...

Chronic dopamine replacement therapy in Parkinson's disease (PD) leads to deleterious motor sequelae known as L-DOPA-induced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [(±)propranolol], a nonselective β-adrenergic receptor (βAR) antagonist, may reduce LID. The present study used the rat unilat...

In concept learning, inductive techniques perform a global approximation to the target concept. Instead, lazy learning techniques use local approximations to form an implicit global approximation of the target concept. In this paper we present C-LID, a lazy learning technique that uses LID for generating local approximations to the target concept. LID generates local approximations in the form ...

Levodopa remains the mainstay of treatment for Parkinson disease (PD), but its use is associated with dyskinesias (LID) in many patients. LID likely reflect dysregulated release of dopamine combined with altered postsynaptic mechanisms due to pulsatile dopamine receptor stimulation. Dopamine D receptors are increased in animal models of LID, and experimental LID is attenuated by suppression of ...

Two experiments tested the roles of hidden toys and motor history in the AB task with l&monthold infants. In Experiment 1 (N = 24), infants were tested in lid and toy versions of the task, each comprised of A and B trials. No toys were ever hidden in the lid condition. On all A trials, an experimenter directed infants’ attention to one of two lids (the A lid) and allowed infants to reach follow...