The authors studied the effect of changes in arterial carbon dioxide tension on plasma tidocaine concentrations dltring a constant lidocaine infusion in eight healthy volunteers. With a PaC02 of 41.4 : 0.9 mmttg (mean • SE). total plasma lido. caine concentrations were 3.97 ~0.20 tzg.ml t. There was no significant change associated with hypercarbia (PaCO 2 = 55~7 • 1.5 mmtfg, lidoeaine = 3.93 •...

The pharmacokinetics of lidocaine deals with the measurement of lidocaine concentration in the blood and its changes over time. The toxicity of lidocaine is a function of its peak plasma concentration, which in turn depends on several factors including total dose and rates of systemic absorption and elimination. The aim of the study was to assess serum levels of lidocaine after a single shot ep...

REASONS FOR PERFORMING STUDY Continuous-rate infusions (CRI) of lidocaine are often used for prolonged duration but, to date, only limited time/concentration relationships administered as a short term (24 h) CRI have been reported. OBJECTIVE To determine the time/concentration profile of lidocaine and its active metabolites glycinexylidide (GX) and monoethylglycinexylidide (MEGX) during a 96 ...

Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

BACKGROUND Topical anesthetics, unlike injectable anesthetics, can be applied painlessly and can provide sufficient pain control to maintain patient comfort throughout a variety of laser procedures. Although the use of topical lidocaine is considered relatively safe, instances of cardiotoxic and neurotoxic adverse events have been reported to occur. OBSERVATIONS A 52-year-old woman underwent ...

Introduction: Lidocaine is a class of Ib antiarrhythmic agent which available in various intravenous (IV) and topical forms. Systemic toxicity lidocaine has been reported following its IV injection or local infiltration for anesthesia, mostly. However, the application gel oral spray also possible. Manifestations induced systemic include neurologic cardiac symptoms. Reported cases after ingestio...

background: lidocaine is a local anesthetic and antiarrhythmic agent. there are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

Mrs. Heidari, 53 developed ventricular fibrillation and cardiopulmonary arrest after receiving 15 mL lidocaine 2% for local anesthesia at the Dr. Shariati Hospital Cathlab. There was no identified risk factor for her arrest preoperatively. She had a history of exertional chest pain for about 5 years and an electrocardiogram showed only inverted T-waves at the time of angiography. The case i...