A kinetic study of the decomposition of pyridine chromium peroxide with methanol, ethanol, propanol and isopropanol has been made over the temperature range 25 to 40°C. It is found that the ligand exchange stage is the rate determining step in the oxidation process. The activation parameters E , ?H‡ and ?S‡ for the reactions are determined. It is believed that the peroxide linkage is primaril...

Electronic Supplementary Information Mechanistic Investigation of Ligand Exchange in Guanidinate Ligand Systems Allison L. Brazeau, Gino A. DiLabio, Kevin A. Kreisel, Wesley Monillas, Glenn P. A. Yap and Seán T. Barry*

Visible spectrophotometry is used to study the kinetics of ligand exchange in the system Ni(salpn)/H2salen with or without triethylamine (NEt3) and H2O in dimethylformamide (DMF) solvent at 25 ± 0.1 °C and 0.01 M NaNO3 [H2salen and H2salpn are N,N’-ethylen-bis(salicylaldimine) and N,N’-propylen-bis(salicylaldimine), respectively]. It was found that the reaction rate is of the first-order with r...

Protein-ligand interactions have been commonly studied through static structures of the protein-ligand complex. Recently, however, there has been increasing interest in investigating the dynamics of protein-ligand interactions both for fundamental understanding of the underlying mechanisms and for drug development. NMR is a versatile and powerful tool, especially because it provides site-specif...