conclusions our findings showed that hcv infection could lead to increased expression level of tlr7 mrna in peripheral blood cells of hcv infected samples. the viral load and genotypes of hcv did not affect the mrna expression levels of tlr2 and tlr7. background hepatitis c virus (hcv) is an important human pathogen affecting an estimated 120 – 170 million individuals in the world. toll-like re...

background: pattern recognition receptors (prrs) are the main sensors of pathogen and danger signals in innate immunity of which toll like receptors (tlrs) are the most studied ones. the contribution of prrs in cerebral inflammation induced by microbial infection, tissue damage and cancer has not extensively been addressed so far. glioma is the most common tumor of the central nervous system an...

toll like receptors (tlrs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. in their bridging role, tlr downstream signals link innate and adaptive immunity, particularly by mediating dc maturation and activation of pathogen specific t lymphocytes. these pathways lead to the act...

background macrophages play critical roles in innate immune response in the liver. whether macrophages participate in liver innate immunity against hcv replication is poorly understood objectives the aim of this study was to investigate the role of macrophages in liver innate immunity against hcv replication. conclusions macrophages may play an important role in liver innate immunity against hc...

background: early childhood caries (ecc) is a common health problem in the developing countries. basic knowledge about the etiology and pathogenesis of ecc plays an important role in its prevention. objective: to determine the relationship between salivary tlr-2 concentration and early childhood caries formation methods: twenty-eight children with ages ranging from 36 to 71 months (15 in ecc gr...

asthma as a chronic inflammatory airway disease is considered to be the most common chronic disease that is involving genetic and environmental factors. toll like receptors (tlrs) and other inflammatory mediators are important in modulation of inflammation. in this study, we evaluated the role of tlr2 arg753gln and tlr4 asp299gly polymorphisms in the asthma susceptibility, progress, control lev...