The cerebral cortex can be functionally subdivided into primary sensory-motor, unimodal association, heteromodal association, paralimbic and limbic regions. Broca was the first who described limbic lobe in 1874, as a ring of gray matter, lying between the diencephalon and more lateral neocortex on the medial surface of the hemisphers. It locates outside of the corpus callosum and consists of su...

The concept of the limbic system is highly influential in many areas of the neurosciences and in their applications to clinical medicine. The value of this concept has been questioned, denied, and defended several times in the past but a comprehensive critical evaluation has never been published. In this article we take several approaches to analyse empirical data of relevance to the limbic sys...

Evolutionarily older brain systems, such as the limbic system, appear to serve fundamental aspects of emotional processing and provide relevant and motivational information for phylogenetically more recent brain systems to regulate complex behaviors. Overall, overt behavior is, in part, determined by the interactions of multiple learning and memory systems, some seemingly complementary and some...

The limbic system is predominantly involved in memory and emotional output. Its 2 principle components are the hippocampus (involved in memory as part of the Papez circuit) and the amygdala (involved in emotional responses, memories and drives). The principle clinical manifestations of limbic disease are epilepsy, confusional states, and cognitive impairment. The connections of the limbic syste...

The limbic system can be considered to consist of a central 'core' from which three well-defined circuits emerge. These are the Papez or medial circuit, the basolateral circuit and the defence reaction circuit. The functions of the primitive limbic brain are modulated by a higher order control-the frontal lobe. Emotional responses and physiological changes have been obtained by stimulation of f...

A 58-yr-old woman developed an extreme acute hypernatremia (serum sodium level 200 mmol/l) with generalized seizures and coma after a laparoscopic intervention for a liver hydatid cyst excision complicated by cyst rupture and followed by a peritoneal sterilization of the cyst content with 30% hypertonic saline solution. Hemodialysis was started with correction of hypernatremia at a speed of 1 m...