This article presents a methodology to solve three dimensional bounded transportation problem. Bounded problem is expounded by defining parallel Equivalence between the two problems established. The proposed model applied public distribution system of North Delhi. A computing software LINGO 17:0 used application.

BACKGROUND Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron and oligodendrocyte survival, axon regeneration, and (re)myelination. The therapeutic effects of ant...

Lingo is an emerging language on the Internet. Providing a standardized definition remains difficult due to continuous changes made to its nature. We proposed Tranzzl!n9o, a crossword puzzle game for engaging crowds to translate Internet lingo. Players provide explanations for lingo in parallel and iteratively verify the explanations from other players. Crowd-sourced translations are very infor...

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane. However, this pathogenic mode of processing AβPP may occur in competition with lysosomal degradation...

Leucine rich repeat proteins have gained considerable interest as therapeutic targets due to their expression and biological activity within the central nervous system. LINGO-1 has received particular attention since it inhibits axonal regeneration after spinal cord injury in a RhoA dependent manner while inhibiting leucine rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-...

Essential tremor (ET), one of the most common adult-onset movement disorders, has been associated with cerebellar Purkinje cell degeneration and formation of brainstem Lewy bodies. Recent findings suggest that genetic variants of the leucine-rich repeat and Ig domain containing 1 (LINGO-1) gene could be risk factors for ET. The LINGO-1 protein contains both leucine-rich repeat (LRR) and immunog...

This paper deals with re-modelling of a fuzzy linear programming (FLP) for an optimal product-mix decision problem and its solution. Database of a chocolate exporting company has been used here to show the practicability of using the proposed model. The proposed model includes a non-linear membership function (MF), a logistic function, which resemblances the realistic behaviour of the solution....

This paper presents the feasibility study of CO2 sequestration from the sources to the sinks in the prospective of Italian Industries. CO2 produced at these sources captured, compressed to supercritical pressures, transported via pipelines and stored in underground geologic formations such as depleted oil and natural gas reservoirs, un-minable coal seams and deep saline aquifers. In this work, ...

Neurotrophins, essential regulators of many aspects of neuronal differentiation and function, signal via four receptors, p75, TrkA, TrkB and TrkC. The three Trk paralogs are members of the LIG superfamily of membrane proteins, which share extracellular domains consisting of leucine-rich repeat and C2 Ig domains. Another LIG protein, LINGO-1 has been reported to bind and influence signaling of p...