PURPOSE To compare the stromal demarcation line depth in pulsed versus continuous corneal cross-linking (CXL) for keratoconus. METHODS Seventy eyes underwent epithelium-off cross-linking, with 0.1% riboflavin applied during 10 minutes prior to ultraviolet irradiation at 30 mW/cm2. Thirty-six eyes received pulsed irradiation (1 second on, 1 second off) for 8 minutes and 34 eyes underwent conti...

The mechanisms underlying the success of UVA–riboflavin collagen cross-linking (CXL) to arrest or allay corneal ectasia are not well understood. One observation that may shed light on the underpinnings of CXL: the cornea thins after the procedure for at least several months. Thinning produces a more compact and stiffer tissue. Normally, corneal thickness is controlled by endothelial active tran...

PURPOSE To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis. METHODS Five patients with infectious keratitis associated with corneal melting were treated with CXL at the outpatient departments of the Institut für Refraktive und Ophthalmo-Chirurgie and the eye hospital at the University of Zurich. CXL was performed when the infection di...

The introduction of corneal cross-linking (CXL) has changed the landscape of treatment and management of keratoconus and ectasia after refractive surgery. Previously, treatment options provided only temporary visual rehabilitation without limiting disease progression. Keratoconus and ectasia resulted in significant vision-related reduction in quality of life and a substantial lifetime economic ...

THE CONCEPT OF CXL In 1998, the proof-of-principle for corneal collagen cross-linking (CXL) was born from such a “simple” concept. Combining ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea could be stiffened within a mere half hour and progressive thinning diseases such as keratoconus could be halted.1,2 Although still considered a relatively new concept, CXL is now i...

Corneal collagen cross-linking (CxL) is a prevalent surgical method for the management of keratoconus. However, literature suggests that, further to keratoconus, CxL has a beneficial impact on a series of corneal related diseases and states. This article attempts to provide a contemporary review for all additional applications of CxL. Specifically, it outlines the most recent studies that demon...

Purpose: To evaluate the efficacy of trans-epithelial cross-linking (TE-CXL) and to compare the visual and topographic outcomes of TE-CXL versus epithelium-off cross-linking (CXL) in adult keratoconus (KC). Design: A prospective non-randomized open case series. Methods: The study enrolled 27 KC eyes of 15 patients treated by TE-CXL (group I) and 35 KC eyes of 20 patients treated by epithelial-o...

Background/Aim. Corneal cross-linking (CXL) treatment shows the best results in stabilizing cornea and stopping progress of ectatic process. The aim study was to assess impact CXL on keratoconus regarding higher-order aberrations (HOAs) potential improvement visual function. Methods. In 19 patients, a standard epithelium-off performed with an energy density three mW/cm2 for half hour. examined ...

Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysis of some established topics and others that are still controversial. In addition, this review ex...

PURPOSE To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). METHODS Case report. RESULTS A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 months after surgery, which did not respond to topical antibiotics. The patie...