colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and ...

Approximately 40 % of newly discovered chemical entities have low solubility and possess bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) recently become very popular because their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying (SEDDS) are one type LBDDS employed for the incorporation hydrophobic drugs. SED...

The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents a major challenge for the drug delivery. To over come this challenge, different methods were developed for the improvement of oral bioavailability, but some have major disadvantages. Recently, oral lipid based formulation is developed for the improvement of ora...

Development of knowledge on lipids has attracted the scientific community for the effective utilization of the natural and synthetic lipids. Bioavailability of poorly water soluble drugs from gastrointestinal tract (GIT) can be enhanced by formulating the drugs in lipid based formulations. This formulation can increase the dissolution of poorly water soluble drugs, and facilitates the formation...